Fabrication of Drug Delivery Systems Using Self-Assembled Peptide Nanostructures

Daniel Keith; Honggang Cui

doi:10.1016/B978-0-323-29642-7.00005-9

Fabrication of Drug Delivery Systems Using Self-Assembled Peptide Nanostructures

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Peptides offer several molecular attributes that enable their unique use for drug delivery. Their chemical design versatility, in combination with their ability to adopt specific secondary structures, provides a unique platform for the design of biomaterials with well-defined structural and biological features. Here we provide a brief review on the use of peptide-based self-assembling nanostructures as carriers to deliver small molecule hydrophobic drugs. We will first outline the rational design principles for constructing a drug delivery system, and then analyze several peptide-based systems that harness such designs.

Original language	English (US)
Title of host publication	Micro and Nanofabrication Using Self-Assembled Biological Nanostructures
Publisher	Elsevier Inc.
Pages	91-115
Number of pages	25
ISBN (Electronic)	9780323296526
ISBN (Print)	9780323296427
DOIs	https://doi.org/10.1016/B978-0-323-29642-7.00005-9
State	Published - 2015
Externally published	Yes

Keywords

Anticancer drugs
Drug delivery
Peptides
Self-assembly
Supramolecular nanostructures

ASJC Scopus subject areas

General Engineering

Access to Document

10.1016/B978-0-323-29642-7.00005-9

Cite this

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abstract = "Peptides offer several molecular attributes that enable their unique use for drug delivery. Their chemical design versatility, in combination with their ability to adopt specific secondary structures, provides a unique platform for the design of biomaterials with well-defined structural and biological features. Here we provide a brief review on the use of peptide-based self-assembling nanostructures as carriers to deliver small molecule hydrophobic drugs. We will first outline the rational design principles for constructing a drug delivery system, and then analyze several peptide-based systems that harness such designs.",

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AU - Cui, Honggang

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AB - Peptides offer several molecular attributes that enable their unique use for drug delivery. Their chemical design versatility, in combination with their ability to adopt specific secondary structures, provides a unique platform for the design of biomaterials with well-defined structural and biological features. Here we provide a brief review on the use of peptide-based self-assembling nanostructures as carriers to deliver small molecule hydrophobic drugs. We will first outline the rational design principles for constructing a drug delivery system, and then analyze several peptide-based systems that harness such designs.

KW - Anticancer drugs

KW - Drug delivery

KW - Peptides

KW - Self-assembly

KW - Supramolecular nanostructures

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SN - 9780323296427

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EP - 115

BT - Micro and Nanofabrication Using Self-Assembled Biological Nanostructures

PB - Elsevier Inc.

ER -

Fabrication of Drug Delivery Systems Using Self-Assembled Peptide Nanostructures

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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