F-cell production in sickle cell anemia: Regulation by genes linked to β-hemoglobin locus

George J. Dover; Samuel H. Boyer; Marcus E. Pembrey

doi:10.1126/science.6162200

F-cell production in sickle cell anemia: Regulation by genes linked to β-hemoglobin locus

George J. Dover, Samuel H. Boyer, Marcus E. Pembrey

Johns Hopkins Hospital

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36 Scopus citations

Abstract

Strong correlation of F-reticulocyte levels within sib pairs with sickle cell (SS) anemia suggests that the wide-ranging levels found in the SS population are governed by genes linked to the β^s-site. Correlations between F-cell levels in parents and F-reticulocyte levels in their children indicates that these same genes regulate F-cell production in nonanemic persons. Comparison of outcrossed and inbred SS populations suggests that relative well-being arises from homozygosity for alleles dictating high F-reticulocyte response to anemia.

Original language	English (US)
Pages (from-to)	1441-1444
Number of pages	4
Journal	Science
Volume	212
Issue number	4489
DOIs	https://doi.org/10.1126/science.6162200
State	Published - 1981

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title = "F-cell production in sickle cell anemia: Regulation by genes linked to β-hemoglobin locus",

abstract = "Strong correlation of F-reticulocyte levels within sib pairs with sickle cell (SS) anemia suggests that the wide-ranging levels found in the SS population are governed by genes linked to the βs-site. Correlations between F-cell levels in parents and F-reticulocyte levels in their children indicates that these same genes regulate F-cell production in nonanemic persons. Comparison of outcrossed and inbred SS populations suggests that relative well-being arises from homozygosity for alleles dictating high F-reticulocyte response to anemia.",

author = "Dover, {George J.} and Boyer, {Samuel H.} and Pembrey, {Marcus E.}",

year = "1981",

doi = "10.1126/science.6162200",

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T1 - F-cell production in sickle cell anemia

T2 - Regulation by genes linked to β-hemoglobin locus

AU - Dover, George J.

AU - Boyer, Samuel H.

AU - Pembrey, Marcus E.

PY - 1981

Y1 - 1981

N2 - Strong correlation of F-reticulocyte levels within sib pairs with sickle cell (SS) anemia suggests that the wide-ranging levels found in the SS population are governed by genes linked to the βs-site. Correlations between F-cell levels in parents and F-reticulocyte levels in their children indicates that these same genes regulate F-cell production in nonanemic persons. Comparison of outcrossed and inbred SS populations suggests that relative well-being arises from homozygosity for alleles dictating high F-reticulocyte response to anemia.

AB - Strong correlation of F-reticulocyte levels within sib pairs with sickle cell (SS) anemia suggests that the wide-ranging levels found in the SS population are governed by genes linked to the βs-site. Correlations between F-cell levels in parents and F-reticulocyte levels in their children indicates that these same genes regulate F-cell production in nonanemic persons. Comparison of outcrossed and inbred SS populations suggests that relative well-being arises from homozygosity for alleles dictating high F-reticulocyte response to anemia.

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JO - Science

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F-cell production in sickle cell anemia: Regulation by genes linked to β-hemoglobin locus

Abstract

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