Extranodal Rosai-Dorfman disease involving the heart: Report of two cases

Joseph J. Maleszewski, Alexandra C. Hristov, Marc K. Halushka, Dylan V. Miller

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) is a rare disease that typically occurs in lymph nodes. While many body sites have been reported to be involved in extranodal manifestations of the disease, the cardiovascular system has been largely absent in this literature. We report two cases of Rosai-Dorfman disease that involves the heart. Case 1 was a 40-year-old man with chronic myelomonocytic leukemia who was incidentally noted to have Rosai-Dorfman disease on autopsy after succumbing to respiratory failure in the setting of adult respiratory distress syndrome. Case 2 was a 57-year-old woman known to have Rosai-Dorfman disease involving mediastinal lymph nodes and found to have a right atrial mass on workup for atypical chest pain. Both cases showed a similar histologic picture of large, multinucleated histiocytes with immunoreactivity to S100, emperipolesis, and marked plamacytosis. This study expands our knowledge of organs involved in extranodal Rosai-Dorfman disease.

Original languageEnglish (US)
Pages (from-to)380-384
Number of pages5
JournalCardiovascular Pathology
Issue number6
StatePublished - Nov 2010


  • Cardiac
  • Extranodal
  • Rosai-Dorfman disease
  • Sinus histiocytosis with massive lymphadenopathy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cardiology and Cardiovascular Medicine


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