TY - JOUR
T1 - Extranodal Head and Neck Lymphoma
T2 - Prognosis and Patterns of Recurrence
AU - Burton, Gary V.
AU - Atwater, Susan
AU - Borowitz, Michael J.
AU - Huang, Andrew T.
PY - 1990/1
Y1 - 1990/1
N2 - Stages I and II extranodal head and neck lymphomas treated between 1969 and 1986 were reviewed to determine prognosis and recurrence patterns. Forty-four patients had low-grade lymphoma, with 57% remaining disease free (median survival, 7.2 years). Radiotherapy provided long-term disease-free survival and palliation in the majority of patients. Relapse did not adversely affect survival. Eighty-eight patients had intermediate- or high-grade lymphoma, with 42% remaining disease free (median survival, 2.4 years). Treatment with radiotherapy alone was inadequate. Combined radiotherapy and anthracycline-containing chemotherapy appeared to be superior. Extranodal sites of first relapse were common. Central nervous system relapse was common with primary tumors located above the pterygopalatine line. Central nervous system staging and prophylactic therapy is warranted in patients with tumors above the pterygopalatine line. (Arch Otolaryngol Head Neck Surg. 1990;116:69-73)
AB - Stages I and II extranodal head and neck lymphomas treated between 1969 and 1986 were reviewed to determine prognosis and recurrence patterns. Forty-four patients had low-grade lymphoma, with 57% remaining disease free (median survival, 7.2 years). Radiotherapy provided long-term disease-free survival and palliation in the majority of patients. Relapse did not adversely affect survival. Eighty-eight patients had intermediate- or high-grade lymphoma, with 42% remaining disease free (median survival, 2.4 years). Treatment with radiotherapy alone was inadequate. Combined radiotherapy and anthracycline-containing chemotherapy appeared to be superior. Extranodal sites of first relapse were common. Central nervous system relapse was common with primary tumors located above the pterygopalatine line. Central nervous system staging and prophylactic therapy is warranted in patients with tumors above the pterygopalatine line. (Arch Otolaryngol Head Neck Surg. 1990;116:69-73)
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U2 - 10.1001/archotol.1990.01870010073021
DO - 10.1001/archotol.1990.01870010073021
M3 - Article
C2 - 2294944
AN - SCOPUS:0025057626
SN - 0886-4470
VL - 116
SP - 69
EP - 73
JO - Archives of Otolaryngology--Head and Neck Surgery
JF - Archives of Otolaryngology--Head and Neck Surgery
IS - 1
ER -