TY - JOUR
T1 - Extraction of weak hydrophobic sulforaphane from broccoli by salting-out assisted hydrophobic deep eutectic solvent extraction
AU - Deng, Wen wen
AU - Mei, Xue ping
AU - Cheng, Zi jun
AU - gan, Tian xiang
AU - Tian, Xuan
AU - Hu, Jiang nan
AU - Zang, Chuan ru
AU - Sun, Bo
AU - Wu, Jing
AU - Deng, Yin
AU - Ghiladi, Reza A.
AU - Lorimer, George H.
AU - Keceli, Gizem
AU - Wang, Jun
N1 - Funding Information:
We thank the Hubei Provincial Department of Education (Q20201406), Hubei University of Technology (BSQD2019033) and National Natural Science Foundation of China TUBITAK (Turkey)-NSFC (China) Bilateral Cooperation Grant (82061138005) for financially supporting this project.
Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2023/3/30
Y1 - 2023/3/30
N2 - In order to extract sulforaphane (SFN) from broccoli via green and efficient ways, a novel method based on salting-out assisted deep eutectic solvent (DES) has been developed. Compared to known organic solvent- (such as dichloromethane, ethyl acetate, n-hexane, etc.) based liquid–liquid extraction, this new N8881Cl-based DES method exhibited excellent extraction efficiency for SFN, including a significant improvement due to the salting-out effect of KH2PO4. Under optimal conditions, 97.77 % of SFN was extracted by N8881Cl-EG DES and more than 82.5 % of SFN was recovered by activated carbon from DES. In addition, further studies with Kamlet-Taft parameters and density functional theory showed that the H-bond accepting capacity of hydrophobic DES, the existing vdW interaction, and the electrostatic interaction between N8881Cl-EG DES all contributed to efficient extraction of SFN. This is the first time that the underlying mechanism for SFN extraction by DES was revealed.
AB - In order to extract sulforaphane (SFN) from broccoli via green and efficient ways, a novel method based on salting-out assisted deep eutectic solvent (DES) has been developed. Compared to known organic solvent- (such as dichloromethane, ethyl acetate, n-hexane, etc.) based liquid–liquid extraction, this new N8881Cl-based DES method exhibited excellent extraction efficiency for SFN, including a significant improvement due to the salting-out effect of KH2PO4. Under optimal conditions, 97.77 % of SFN was extracted by N8881Cl-EG DES and more than 82.5 % of SFN was recovered by activated carbon from DES. In addition, further studies with Kamlet-Taft parameters and density functional theory showed that the H-bond accepting capacity of hydrophobic DES, the existing vdW interaction, and the electrostatic interaction between N8881Cl-EG DES all contributed to efficient extraction of SFN. This is the first time that the underlying mechanism for SFN extraction by DES was revealed.
KW - 1,4- Butanediol (PubChem CID 8064)
KW - Broccoli
KW - Deep eutectic solvent
KW - Density functional theory
KW - Ethylene glycol (PubChem CID 174)
KW - Glycerol (PubChem CID 753)
KW - Hydrophobic
KW - Kamlet-Taft parameters
KW - Lidocaine (PubChem CID 3676)
KW - Methyl trioctyl ammonium chloride (PubChem CID 21218)
KW - N-capric acid (PubChem CID 2969)
KW - N-octanoic acid (PubChem CID 379)
KW - Sulforaphane
KW - Sulforaphane (PubChem CID 5350)
KW - Thymol (PubChem CID 6989)
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U2 - 10.1016/j.foodchem.2022.134817
DO - 10.1016/j.foodchem.2022.134817
M3 - Article
C2 - 36370577
AN - SCOPUS:85141516657
SN - 0308-8146
VL - 405
JO - Food Chemistry
JF - Food Chemistry
M1 - 134817
ER -