Extracellular vs. intracellular pH as a determinant of myocardial contractility

H. E. Cingolani, E. S. Blesa, N. C. Gonzalez, A. Mattiazzi

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Papillary muscles from the right ventricle of the cat were isolated in a chamber, and exposed to Ringer's solutions with different NaHCO3 concentration and pCO2, but with the same pH. When a Ringer solution containing 35 mM/1 and pCO2 40 mmHg was changed to another containing NaHCO3 80 mM/1 and pCO2 90 mmHg, a decrease in contractility, evidenced by a decrease in developed tension(DT) and rate of rise of the tension (dp/dt) without changes in the time to peak tension (TTP) was observed, in spite of the fact that pH reimained unchanged (7.40). It is concluded that extracellular pH is not a major determinant of the changes in myocardial contractility that follow acid base alterations.

Original languageEnglish (US)
Pages (from-to)775-781
Number of pages7
JournalLife Sciences
Issue number13 PART 1
StatePublished - Jul 1 1969
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • Pharmacology, Toxicology and Pharmaceutics(all)


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