Abstract
Papillary muscles from the right ventricle of the cat were isolated in a chamber, and exposed to Ringer's solutions with different NaHCO3 concentration and pCO2, but with the same pH. When a Ringer solution containing 35 mM/1 and pCO2 40 mmHg was changed to another containing NaHCO3 80 mM/1 and pCO2 90 mmHg, a decrease in contractility, evidenced by a decrease in developed tension(DT) and rate of rise of the tension (dp/dt) without changes in the time to peak tension (TTP) was observed, in spite of the fact that pH reimained unchanged (7.40). It is concluded that extracellular pH is not a major determinant of the changes in myocardial contractility that follow acid base alterations.
Original language | English (US) |
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Pages (from-to) | 775-781 |
Number of pages | 7 |
Journal | Life Sciences |
Volume | 8 |
Issue number | 13 PART 1 |
DOIs | |
State | Published - Jul 1 1969 |
Externally published | Yes |
ASJC Scopus subject areas
- General Pharmacology, Toxicology and Pharmaceutics
- General Biochemistry, Genetics and Molecular Biology