Extracellular potassium and blood flow in the post-ischemic rat brain

A. J. Hansen; A. Gjedde; E. Siemkowicz

doi:10.1007/BF00587921

Extracellular potassium and blood flow in the post-ischemic rat brain

A. J. Hansen, A. Gjedde, E. Siemkowicz

School of Medicine

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

The concentration of extracellular potassium, [K⁺]_e, was measured in parietal cortex and basal ganglia of rats during and after ten minutes of complete cerebral ischemia. The post-ischemic normalization of [K⁺]_e was considerably delayed in parietal cortex compared to basal ganglia, but in both regions, [K⁺]_e reached its normal concentration within 4 min of the end of the ischemia. Also, in both regions blood flow was elevated at the time of maximal [K⁺]₃ decrease. Our findings suggest that the normalization of [K⁺]_e and cerebrovascular resistance after ischemia are related by positive feed-back, possibly via the stimulation of Na⁺-K⁺-ATPase.

Original language	English (US)
Pages (from-to)	1-7
Number of pages	7
Journal	Pflügers Archiv European Journal of Physiology
Volume	389
Issue number	1
DOIs	https://doi.org/10.1007/BF00587921
State	Published - Dec 1 1980

Keywords

Cerebral blood flow
Cerebral ischemia
Extracellular potassium

ASJC Scopus subject areas

Physiology
Clinical Biochemistry
Physiology (medical)

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10.1007/BF00587921

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N2 - The concentration of extracellular potassium, [K+]e, was measured in parietal cortex and basal ganglia of rats during and after ten minutes of complete cerebral ischemia. The post-ischemic normalization of [K+]e was considerably delayed in parietal cortex compared to basal ganglia, but in both regions, [K+]e reached its normal concentration within 4 min of the end of the ischemia. Also, in both regions blood flow was elevated at the time of maximal [K+]3 decrease. Our findings suggest that the normalization of [K+]e and cerebrovascular resistance after ischemia are related by positive feed-back, possibly via the stimulation of Na+-K+-ATPase.

AB - The concentration of extracellular potassium, [K+]e, was measured in parietal cortex and basal ganglia of rats during and after ten minutes of complete cerebral ischemia. The post-ischemic normalization of [K+]e was considerably delayed in parietal cortex compared to basal ganglia, but in both regions, [K+]e reached its normal concentration within 4 min of the end of the ischemia. Also, in both regions blood flow was elevated at the time of maximal [K+]3 decrease. Our findings suggest that the normalization of [K+]e and cerebrovascular resistance after ischemia are related by positive feed-back, possibly via the stimulation of Na+-K+-ATPase.

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Extracellular potassium and blood flow in the post-ischemic rat brain

Abstract

Keywords

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