Extracellular crosstalk: When GDNF meets N-CAM

Feng Quan Zhou, Jian Zhong, William D. Snider

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


N-CAM has now been identified as a receptor for glial cell line-derived neurotrophic factor (GDNF). This finding solves a long-standing question regarding RET-independent GDNF signaling, and reveals a novel pathway distinct from both GDNF-RET and N-CAM-N-CAM signaling. Functional assays of Schwann cell migration and axon growth of CNS neurons suggest physiological significance for this GDNF-N-CAM pathway.

Original languageEnglish (US)
Pages (from-to)814-815
Number of pages2
Issue number7
StatePublished - Jun 27 2003
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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