Extracellular crosstalk: When GDNF meets N-CAM

Feng Quan Zhou; Jian Zhong; William D. Snider

doi:10.1016/S0092-8674(03)00467-7

Extracellular crosstalk: When GDNF meets N-CAM

Feng Quan Zhou, Jian Zhong, William D. Snider

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

N-CAM has now been identified as a receptor for glial cell line-derived neurotrophic factor (GDNF). This finding solves a long-standing question regarding RET-independent GDNF signaling, and reveals a novel pathway distinct from both GDNF-RET and N-CAM-N-CAM signaling. Functional assays of Schwann cell migration and axon growth of CNS neurons suggest physiological significance for this GDNF-N-CAM pathway.

Original language	English (US)
Pages (from-to)	814-815
Number of pages	2
Journal	Cell
Volume	113
Issue number	7
DOIs	https://doi.org/10.1016/S0092-8674(03)00467-7
State	Published - Jun 27 2003
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/S0092-8674(03)00467-7

Cite this

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title = "Extracellular crosstalk: When GDNF meets N-CAM",

abstract = "N-CAM has now been identified as a receptor for glial cell line-derived neurotrophic factor (GDNF). This finding solves a long-standing question regarding RET-independent GDNF signaling, and reveals a novel pathway distinct from both GDNF-RET and N-CAM-N-CAM signaling. Functional assays of Schwann cell migration and axon growth of CNS neurons suggest physiological significance for this GDNF-N-CAM pathway.",

author = "Zhou, {Feng Quan} and Jian Zhong and Snider, {William D.}",

year = "2003",

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T2 - When GDNF meets N-CAM

AU - Zhou, Feng Quan

AU - Zhong, Jian

AU - Snider, William D.

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Y1 - 2003/6/27

N2 - N-CAM has now been identified as a receptor for glial cell line-derived neurotrophic factor (GDNF). This finding solves a long-standing question regarding RET-independent GDNF signaling, and reveals a novel pathway distinct from both GDNF-RET and N-CAM-N-CAM signaling. Functional assays of Schwann cell migration and axon growth of CNS neurons suggest physiological significance for this GDNF-N-CAM pathway.

AB - N-CAM has now been identified as a receptor for glial cell line-derived neurotrophic factor (GDNF). This finding solves a long-standing question regarding RET-independent GDNF signaling, and reveals a novel pathway distinct from both GDNF-RET and N-CAM-N-CAM signaling. Functional assays of Schwann cell migration and axon growth of CNS neurons suggest physiological significance for this GDNF-N-CAM pathway.

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DO - 10.1016/S0092-8674(03)00467-7

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JO - Cell

JF - Cell

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Extracellular crosstalk: When GDNF meets N-CAM

Abstract

ASJC Scopus subject areas

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