Abstract
PURPOSE OF REVIEW: This review will summarize recent literature highlighting the roles of sensory Gpr receptors and their roles in renal function. RECENT FINDINGS: Chemoreceptors play important roles in renal physiology wherein they modulate renal function in response to ligands from a variety of sources. SUMMARY: As specialized chemical detectors, chemoreceptors in the kidney monitor the level of a variety of chemical ligands in the body and adjust renal function accordingly. In addition to olfactory receptors and taste receptors, G-protein coupled receptors of the orphan Gpr family are now being found to play a 'sensory' role in renal physiology. Identifying the physiological roles of these receptors and elucidating the cell biology underlying these signaling pathways can give us novel insights into renal function.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 507-512 |
| Number of pages | 6 |
| Journal | Current opinion in nephrology and hypertension |
| Volume | 23 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 2014 |
Keywords
- ORs
- chemoreceptor
- kidney
- olfactory receptor
- renal
ASJC Scopus subject areas
- Internal Medicine
- Nephrology