TY - JOUR
T1 - Exserohilum rostratum
T2 - Anatomy of a national outbreak of fungal meningitis
AU - Larone, Davise H.
AU - Walsh, Thomas J.
PY - 2013/12/1
Y1 - 2013/12/1
N2 - On 18 September 2012, an alert physician caring for a patient with fungal meningitis who had received an epidural methylprednisolone acetate injection approximately 6 weeks earlier, recognized its possible significance and reported this case to the Tennessee Department of Health, who in turn notified the Centers for Disease Control and Prevention. Shortly thereafter, additional cases of fungal meningitis were reported, and so began a large, unprecedented, multistate fungal meningitis outbreak. The predominant etiologic agent was Exserohilum rostratum, a black mould that was not known to have previously caused an outbreak of such devastating disease of this magnitude. The contaminated medication was prepared and distributed by a compounding pharmacy located in Massachusetts. This article reviews (i) the development and handling of the outbreak; (ii) the clinical manifestations and management of the infections; (iii) the detection, identification, and characteristics of E. rostratum, including the factors that might enhance its virulence; (iv) the regulatory concerns for microbiological quality control; and (v) what we have learned from this experience.
AB - On 18 September 2012, an alert physician caring for a patient with fungal meningitis who had received an epidural methylprednisolone acetate injection approximately 6 weeks earlier, recognized its possible significance and reported this case to the Tennessee Department of Health, who in turn notified the Centers for Disease Control and Prevention. Shortly thereafter, additional cases of fungal meningitis were reported, and so began a large, unprecedented, multistate fungal meningitis outbreak. The predominant etiologic agent was Exserohilum rostratum, a black mould that was not known to have previously caused an outbreak of such devastating disease of this magnitude. The contaminated medication was prepared and distributed by a compounding pharmacy located in Massachusetts. This article reviews (i) the development and handling of the outbreak; (ii) the clinical manifestations and management of the infections; (iii) the detection, identification, and characteristics of E. rostratum, including the factors that might enhance its virulence; (iv) the regulatory concerns for microbiological quality control; and (v) what we have learned from this experience.
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U2 - 10.1016/j.clinmicnews.2013.11.001
DO - 10.1016/j.clinmicnews.2013.11.001
M3 - Article
AN - SCOPUS:84888196315
SN - 0196-4399
VL - 35
SP - 185
EP - 193
JO - Clinical Microbiology Newsletter
JF - Clinical Microbiology Newsletter
IS - 23
ER -