Expression patterns of cardiac aging in Drosophila

Leah Cannon, Alexander C. Zambon, Anthony Cammarato, Zhi Zhang, Georg Vogler, Matthew Munoz, Erika Taylor, Jérôme Cartry, Sanford I. Bernstein, Simon Melov, Rolf Bodmer

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Aging causes cardiac dysfunction, often leading to heart failure and death. The molecular basis of age-associated changes in cardiac structure and function is largely unknown. The fruit fly, Drosophila melanogaster, is well-suited to investigate the genetics of cardiac aging. Flies age rapidly over the course of weeks, benefit from many tools to easily manipulate their genome, and their heart has significant genetic and phenotypic similarities to the human heart. Here, we performed a cardiac-specific gene expression study on aging Drosophila and carried out a comparative meta-analysis with published rodent data. Pathway level transcriptome comparisons suggest that age-related, extra-cellular matrix remodeling and alterations in mitochondrial metabolism, protein handling, and contractile functions are conserved between Drosophila and rodent hearts. However, expression of only a few individual genes similarly changed over time between and even within species. We also examined gene expression in single fly hearts and found significant variability as has been reported in rodents. We propose that individuals may arrive at similar cardiac aging phenotypes via dissimilar transcriptional changes, including those in transcription factors and micro-RNAs. Finally, our data suggest the transcription factor Odd-skipped, which is essential for normal heart development, is also a crucial regulator of cardiac aging.

Original languageEnglish (US)
Pages (from-to)82-92
Number of pages11
JournalAging Cell
Issue number1
StatePublished - Feb 1 2017


  • LysX
  • MMP1
  • Odd-skipped
  • arrhythmia
  • cardiomyopathy
  • heart
  • nanofluidics
  • senescence

ASJC Scopus subject areas

  • Aging
  • Cell Biology


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