Expression of the sea urchin MyoD homologue, SUM1, is not restricted to the myogenic lineage during embryogenesis

Rebecca L. Beach; Philip Seo; Judith M. Venuti

doi:10.1016/S0925-4773(99)00118-5

Expression of the sea urchin MyoD homologue, SUM1, is not restricted to the myogenic lineage during embryogenesis

Rebecca L. Beach, Philip Seo, Judith M. Venuti

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

SUM1 (sea urchin myogenic factor 1) is a sea urchin homologue of the myogenic basic helix-loop-helix transcription factors of the MyoD family. SUM1 was initially cloned from Lytechinus variegatus where immunocytochemistry demonstrated restricted expression in precursors of the circumesophageal muscles, the only identified muscle cells in the early embryo. Subsequent in situ hybridization analysis indicates that SUM1 embryonic expression is not restricted to the myogenic lineage; a distinct population of nonmyogenic cells also expresses SUM1. For comparative purposes, we cloned the SUM1 orthologue in the distantly related sea urchin, Strongylocentrotus purpuratus, where we found SpSUM1 transcripts in the same population of nonmyogenic cells. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	209-212
Number of pages	4
Journal	Mechanisms of Development
Volume	86
Issue number	1-2
DOIs	https://doi.org/10.1016/S0925-4773(99)00118-5
State	Published - Aug 1 1999
Externally published	Yes

Keywords

Circumesophageal muscles
In situ hybridization
Localization
MyoD
Myogenic determination
SUM1
Sea urchin
Specification, Larvae
Transcription factors
bHLHs

ASJC Scopus subject areas

Embryology
Developmental Biology

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10.1016/S0925-4773(99)00118-5

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title = "Expression of the sea urchin MyoD homologue, SUM1, is not restricted to the myogenic lineage during embryogenesis",

abstract = "SUM1 (sea urchin myogenic factor 1) is a sea urchin homologue of the myogenic basic helix-loop-helix transcription factors of the MyoD family. SUM1 was initially cloned from Lytechinus variegatus where immunocytochemistry demonstrated restricted expression in precursors of the circumesophageal muscles, the only identified muscle cells in the early embryo. Subsequent in situ hybridization analysis indicates that SUM1 embryonic expression is not restricted to the myogenic lineage; a distinct population of nonmyogenic cells also expresses SUM1. For comparative purposes, we cloned the SUM1 orthologue in the distantly related sea urchin, Strongylocentrotus purpuratus, where we found SpSUM1 transcripts in the same population of nonmyogenic cells. Copyright (C) 1999 Elsevier Science Ireland Ltd.",

keywords = "Circumesophageal muscles, In situ hybridization, Localization, MyoD, Myogenic determination, SUM1, Sea urchin, Specification, Larvae, Transcription factors, bHLHs",

author = "Beach, {Rebecca L.} and Philip Seo and Venuti, {Judith M.}",

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T1 - Expression of the sea urchin MyoD homologue, SUM1, is not restricted to the myogenic lineage during embryogenesis

AU - Beach, Rebecca L.

AU - Seo, Philip

AU - Venuti, Judith M.

PY - 1999/8/1

Y1 - 1999/8/1

N2 - SUM1 (sea urchin myogenic factor 1) is a sea urchin homologue of the myogenic basic helix-loop-helix transcription factors of the MyoD family. SUM1 was initially cloned from Lytechinus variegatus where immunocytochemistry demonstrated restricted expression in precursors of the circumesophageal muscles, the only identified muscle cells in the early embryo. Subsequent in situ hybridization analysis indicates that SUM1 embryonic expression is not restricted to the myogenic lineage; a distinct population of nonmyogenic cells also expresses SUM1. For comparative purposes, we cloned the SUM1 orthologue in the distantly related sea urchin, Strongylocentrotus purpuratus, where we found SpSUM1 transcripts in the same population of nonmyogenic cells. Copyright (C) 1999 Elsevier Science Ireland Ltd.

AB - SUM1 (sea urchin myogenic factor 1) is a sea urchin homologue of the myogenic basic helix-loop-helix transcription factors of the MyoD family. SUM1 was initially cloned from Lytechinus variegatus where immunocytochemistry demonstrated restricted expression in precursors of the circumesophageal muscles, the only identified muscle cells in the early embryo. Subsequent in situ hybridization analysis indicates that SUM1 embryonic expression is not restricted to the myogenic lineage; a distinct population of nonmyogenic cells also expresses SUM1. For comparative purposes, we cloned the SUM1 orthologue in the distantly related sea urchin, Strongylocentrotus purpuratus, where we found SpSUM1 transcripts in the same population of nonmyogenic cells. Copyright (C) 1999 Elsevier Science Ireland Ltd.

KW - Circumesophageal muscles

KW - In situ hybridization

KW - Localization

KW - MyoD

KW - Myogenic determination

KW - SUM1

KW - Sea urchin

KW - Specification, Larvae

KW - Transcription factors

KW - bHLHs

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Expression of the sea urchin MyoD homologue, SUM1, is not restricted to the myogenic lineage during embryogenesis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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