TY - JOUR
T1 - Expression of MYD88 in Adipose Tissue of Obese People
T2 - Is There Some Role in the Development of Metabolic Syndrome?
AU - Cuevas, Ada M.
AU - Lazo, Mariana
AU - Zuñiga, Isabel
AU - Carrasco, Fernando
AU - Potter, Jim J.
AU - Alvarez, Veronica
AU - Berry, Marcos
AU - Maluenda, Fernando
AU - Ferrario, Mario
AU - Clark, Jeanne M.
N1 - Publisher Copyright:
© Copyright 2017, Mary Ann Liebert, Inc. 2017.
PY - 2017/3
Y1 - 2017/3
N2 - Background: The mechanism leading to the development of metabolic complications in obese individuals is not fully understood. Thus, the objective of this study was to examine differences in insulin resistance, inflammation, cytokine and adipokine levels, and expression of selected genes across obese individuals with different number of metabolic syndrome (MetS) components. Methods: Forty obese individuals who underwent bariatric surgery, divided in three groups based on the number of components of MetS, in addition to abdominal obesity (0, 1, and 2-3 additional components), were studied. Levels of inflammatory proteins, insulin resistance, cytokines, adipokines, and gene expression in subcutaneous (SAT) and visceral adipose tissue (VAT) were compared. Results: There was a significantly higher expression of MYD88 in SAT among those with more components of MetS (P = 0.008). In SAT, but not in VAT, MYD88 expression was significantly correlated with toll-like receptor 4 expression (r = 0.7, P < 0.05). Expression of adipsin in SAT was also associated with the presence of more components of MetS, but with borderline statistical significance (P = 0.05). There were no significant differences in insulin resistance, inflammation, and cytokine and adipokine levels by the number of components of MetS. Conclusions: Our study suggests that MYD88 expression in SAT of obese subjects could be associated with the development of components of MetS.
AB - Background: The mechanism leading to the development of metabolic complications in obese individuals is not fully understood. Thus, the objective of this study was to examine differences in insulin resistance, inflammation, cytokine and adipokine levels, and expression of selected genes across obese individuals with different number of metabolic syndrome (MetS) components. Methods: Forty obese individuals who underwent bariatric surgery, divided in three groups based on the number of components of MetS, in addition to abdominal obesity (0, 1, and 2-3 additional components), were studied. Levels of inflammatory proteins, insulin resistance, cytokines, adipokines, and gene expression in subcutaneous (SAT) and visceral adipose tissue (VAT) were compared. Results: There was a significantly higher expression of MYD88 in SAT among those with more components of MetS (P = 0.008). In SAT, but not in VAT, MYD88 expression was significantly correlated with toll-like receptor 4 expression (r = 0.7, P < 0.05). Expression of adipsin in SAT was also associated with the presence of more components of MetS, but with borderline statistical significance (P = 0.05). There were no significant differences in insulin resistance, inflammation, and cytokine and adipokine levels by the number of components of MetS. Conclusions: Our study suggests that MYD88 expression in SAT of obese subjects could be associated with the development of components of MetS.
KW - inflammation
KW - metabolic syndrome
KW - myd88
KW - obesity
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U2 - 10.1089/met.2016.0104
DO - 10.1089/met.2016.0104
M3 - Article
C2 - 28075222
AN - SCOPUS:85014055091
SN - 1540-4196
VL - 15
SP - 80
EP - 85
JO - Metabolic Syndrome and Related Disorders
JF - Metabolic Syndrome and Related Disorders
IS - 2
ER -