Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis

J. W R Mulder; V. J M Wielenga; M. M. Polak; F. M. Van Den Berg; G. R. Adolf; P. Herrlich; S. T. Pals; G. J A Offerhaus

Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis

J. W R Mulder, V. J M Wielenga, M. M. Polak, F. M. Van Den Berg, G. R. Adolf, P. Herrlich, S. T. Pals, G. J A Offerhaus

Research output: Contribution to journal › Article › peer-review

Abstract

Colorectal tumorigenesis evolves through a series of molecular genetic changes, providing putative markers for tumour progression. This study investigated the relation between expression of the tumour suppressor gene p53 and splice variants v5 and v6 of the cell adhesion molecule CD44 by immunohistochemistry on tissue samples of early adenomas (n=12), late adenomas (n=12), Dukes's A and B carcinomas (n=21), and Dukes's C and D carcinomas (n=22) and compared these results with expression of these proteins in normal colonic mucosa (n= 17). A statistically significant trend of increasing expression was seen for both p53 (p

Original language	English (US)
Pages (from-to)	76-80
Number of pages	5
Journal	Gut
Volume	36
Issue number	1
State	Published - 1995
Externally published	Yes

Keywords

Adenoma
Cancer
CD44
Colon
p53

ASJC Scopus subject areas

Gastroenterology

Cite this

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title = "Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis",

abstract = "Colorectal tumorigenesis evolves through a series of molecular genetic changes, providing putative markers for tumour progression. This study investigated the relation between expression of the tumour suppressor gene p53 and splice variants v5 and v6 of the cell adhesion molecule CD44 by immunohistochemistry on tissue samples of early adenomas (n=12), late adenomas (n=12), Dukes's A and B carcinomas (n=21), and Dukes's C and D carcinomas (n=22) and compared these results with expression of these proteins in normal colonic mucosa (n= 17). A statistically significant trend of increasing expression was seen for both p53 (p",

keywords = "Adenoma, Cancer, CD44, Colon, p53",

author = "Mulder, {J. W R} and Wielenga, {V. J M} and Polak, {M. M.} and {Van Den Berg}, {F. M.} and Adolf, {G. R.} and P. Herrlich and Pals, {S. T.} and Offerhaus, {G. J A}",

year = "1995",

language = "English (US)",

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pages = "76--80",

journal = "Gut",

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T1 - Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis

AU - Mulder, J. W R

AU - Wielenga, V. J M

AU - Polak, M. M.

AU - Van Den Berg, F. M.

AU - Adolf, G. R.

AU - Herrlich, P.

AU - Pals, S. T.

AU - Offerhaus, G. J A

PY - 1995

Y1 - 1995

N2 - Colorectal tumorigenesis evolves through a series of molecular genetic changes, providing putative markers for tumour progression. This study investigated the relation between expression of the tumour suppressor gene p53 and splice variants v5 and v6 of the cell adhesion molecule CD44 by immunohistochemistry on tissue samples of early adenomas (n=12), late adenomas (n=12), Dukes's A and B carcinomas (n=21), and Dukes's C and D carcinomas (n=22) and compared these results with expression of these proteins in normal colonic mucosa (n= 17). A statistically significant trend of increasing expression was seen for both p53 (p

AB - Colorectal tumorigenesis evolves through a series of molecular genetic changes, providing putative markers for tumour progression. This study investigated the relation between expression of the tumour suppressor gene p53 and splice variants v5 and v6 of the cell adhesion molecule CD44 by immunohistochemistry on tissue samples of early adenomas (n=12), late adenomas (n=12), Dukes's A and B carcinomas (n=21), and Dukes's C and D carcinomas (n=22) and compared these results with expression of these proteins in normal colonic mucosa (n= 17). A statistically significant trend of increasing expression was seen for both p53 (p

KW - Adenoma

KW - Cancer

KW - CD44

KW - Colon

KW - p53

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Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis

Abstract

Keywords

ASJC Scopus subject areas

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