Expression and distribution of CC chemokine macrophage inflammatory protein-1α/LD78 in the human brain

Koko Ishizuka; Ruriko Igata-Yi; Takemi Kimura; Kunio Hieshima; Toshio Kukita; Yosiaki Kin; Yoshio Misumi; Masaaki Yamamoto; Hisayuki Nomiyama; Retsu Miura; Junichi Takamatsu; Shoichi Katsuragi; Taihei Miyakawa

doi:10.1097/00001756-199703240-00031

Expression and distribution of CC chemokine macrophage inflammatory protein-1α/LD78 in the human brain

Koko Ishizuka, Ruriko Igata-Yi, Takemi Kimura, Kunio Hieshima, Toshio Kukita, Yosiaki Kin, Yoshio Misumi, Masaaki Yamamoto, Hisayuki Nomiyama, Retsu Miura, Junichi Takamatsu, Shoichi Katsuragi, Taihei Miyakawa

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Macrophage inflammatory protein (MIP)-1α, also known as LD78, is a member of a family of chemokines which recruit leukocytes to sites of inflammation. We have shown by Northern blot analyses that MIP-1α mRNA is expressed in several human tissues, including brain. To explore MIP-1α distribution in brain tissue, we immunohistochemically examined brain tissues from 13 neuropsychiatric patients. Glial cells in the white matter of brain tissues from four patients with schizophrenia and one with manic depressive illness were MIP-1α positive. Glial cells in the cortex from these patients were negative, except in one patient with schizophrenia in whom neurones as well as glial cells in the cortex stained positively for MIP-1α. In situ hybridization showed that MIP-1α mRNA was expressed in both neurones as well as glial cells in this patient. These results suggest a heterogeneous distribution of MIP-1α in human brain.

Original language	English (US)
Pages (from-to)	1215-1218
Number of pages	4
Journal	Neuroreport
Volume	8
Issue number	5
DOIs	https://doi.org/10.1097/00001756-199703240-00031
State	Published - 1997
Externally published	Yes

Keywords

LD78
chemokines
glial cells
macrophage inflammatory protein-1α
mental disease
neurones
schizophrenia

ASJC Scopus subject areas

Neuroscience(all)

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10.1097/00001756-199703240-00031

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title = "Expression and distribution of CC chemokine macrophage inflammatory protein-1α/LD78 in the human brain",

abstract = "Macrophage inflammatory protein (MIP)-1α, also known as LD78, is a member of a family of chemokines which recruit leukocytes to sites of inflammation. We have shown by Northern blot analyses that MIP-1α mRNA is expressed in several human tissues, including brain. To explore MIP-1α distribution in brain tissue, we immunohistochemically examined brain tissues from 13 neuropsychiatric patients. Glial cells in the white matter of brain tissues from four patients with schizophrenia and one with manic depressive illness were MIP-1α positive. Glial cells in the cortex from these patients were negative, except in one patient with schizophrenia in whom neurones as well as glial cells in the cortex stained positively for MIP-1α. In situ hybridization showed that MIP-1α mRNA was expressed in both neurones as well as glial cells in this patient. These results suggest a heterogeneous distribution of MIP-1α in human brain.",

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author = "Koko Ishizuka and Ruriko Igata-Yi and Takemi Kimura and Kunio Hieshima and Toshio Kukita and Yosiaki Kin and Yoshio Misumi and Masaaki Yamamoto and Hisayuki Nomiyama and Retsu Miura and Junichi Takamatsu and Shoichi Katsuragi and Taihei Miyakawa",

year = "1997",

doi = "10.1097/00001756-199703240-00031",

language = "English (US)",

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AU - Ishizuka, Koko

AU - Igata-Yi, Ruriko

AU - Kimura, Takemi

AU - Hieshima, Kunio

AU - Kukita, Toshio

AU - Kin, Yosiaki

AU - Misumi, Yoshio

AU - Yamamoto, Masaaki

AU - Nomiyama, Hisayuki

AU - Miura, Retsu

AU - Takamatsu, Junichi

AU - Katsuragi, Shoichi

AU - Miyakawa, Taihei

PY - 1997

Y1 - 1997

N2 - Macrophage inflammatory protein (MIP)-1α, also known as LD78, is a member of a family of chemokines which recruit leukocytes to sites of inflammation. We have shown by Northern blot analyses that MIP-1α mRNA is expressed in several human tissues, including brain. To explore MIP-1α distribution in brain tissue, we immunohistochemically examined brain tissues from 13 neuropsychiatric patients. Glial cells in the white matter of brain tissues from four patients with schizophrenia and one with manic depressive illness were MIP-1α positive. Glial cells in the cortex from these patients were negative, except in one patient with schizophrenia in whom neurones as well as glial cells in the cortex stained positively for MIP-1α. In situ hybridization showed that MIP-1α mRNA was expressed in both neurones as well as glial cells in this patient. These results suggest a heterogeneous distribution of MIP-1α in human brain.

AB - Macrophage inflammatory protein (MIP)-1α, also known as LD78, is a member of a family of chemokines which recruit leukocytes to sites of inflammation. We have shown by Northern blot analyses that MIP-1α mRNA is expressed in several human tissues, including brain. To explore MIP-1α distribution in brain tissue, we immunohistochemically examined brain tissues from 13 neuropsychiatric patients. Glial cells in the white matter of brain tissues from four patients with schizophrenia and one with manic depressive illness were MIP-1α positive. Glial cells in the cortex from these patients were negative, except in one patient with schizophrenia in whom neurones as well as glial cells in the cortex stained positively for MIP-1α. In situ hybridization showed that MIP-1α mRNA was expressed in both neurones as well as glial cells in this patient. These results suggest a heterogeneous distribution of MIP-1α in human brain.

KW - LD78

KW - chemokines

KW - glial cells

KW - macrophage inflammatory protein-1α

KW - mental disease

KW - neurones

KW - schizophrenia

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Expression and distribution of CC chemokine macrophage inflammatory protein-1α/LD78 in the human brain

Abstract

Keywords

ASJC Scopus subject areas

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