Explosive Blast Loading on Human 3D Aggregate Minibrains

Nicole E. Zander; Thuvan Piehler; Helena Hogberg; David Pamies

doi:10.1007/s10571-017-0463-7

Explosive Blast Loading on Human 3D Aggregate Minibrains

Nicole E. Zander, Thuvan Piehler, Helena Hogberg, David Pamies

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The effects of primary explosive blast on brain tissue still remain mostly unknown. There are few in vitro models that use real explosives to probe the mechanisms of injury at the cellular level. In this work, 3D aggregates of human brain cells or brain microphysiological system were exposed to military explosives at two different pressures (50 and 100 psi). Results indicate that membrane damage and oxidative stress increased with blast pressure, but cell death remained minimal.

Original language	English (US)
Pages (from-to)	1331-1334
Number of pages	4
Journal	Cellular and molecular neurobiology
Volume	37
Issue number	7
DOIs	https://doi.org/10.1007/s10571-017-0463-7
State	Published - Oct 1 2017

Keywords

Explosives
In vitro model
Induced pluripotent stem cells
Minibrain
Primary blast
Traumatic brain injury

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Cell Biology

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abstract = "The effects of primary explosive blast on brain tissue still remain mostly unknown. There are few in vitro models that use real explosives to probe the mechanisms of injury at the cellular level. In this work, 3D aggregates of human brain cells or brain microphysiological system were exposed to military explosives at two different pressures (50 and 100 psi). Results indicate that membrane damage and oxidative stress increased with blast pressure, but cell death remained minimal.",

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AU - Piehler, Thuvan

AU - Hogberg, Helena

AU - Pamies, David

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N2 - The effects of primary explosive blast on brain tissue still remain mostly unknown. There are few in vitro models that use real explosives to probe the mechanisms of injury at the cellular level. In this work, 3D aggregates of human brain cells or brain microphysiological system were exposed to military explosives at two different pressures (50 and 100 psi). Results indicate that membrane damage and oxidative stress increased with blast pressure, but cell death remained minimal.

AB - The effects of primary explosive blast on brain tissue still remain mostly unknown. There are few in vitro models that use real explosives to probe the mechanisms of injury at the cellular level. In this work, 3D aggregates of human brain cells or brain microphysiological system were exposed to military explosives at two different pressures (50 and 100 psi). Results indicate that membrane damage and oxidative stress increased with blast pressure, but cell death remained minimal.

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KW - In vitro model

KW - Induced pluripotent stem cells

KW - Minibrain

KW - Primary blast

KW - Traumatic brain injury

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Explosive Blast Loading on Human 3D Aggregate Minibrains

Abstract

Keywords

ASJC Scopus subject areas

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