TY - JOUR
T1 - Exploring potential sources of differential vulnerability and susceptibility in risk from environmental hazards to expand the scope of risk assessment
AU - Schwartz, Joel
AU - Bellinger, David
AU - Glass, Thomas
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Genetic factors, other exposures, individual disease states and allostatic load, psychosocial stress, and socioeconomic position all have the potentialtomodify the response to environmental exposures. Moreover, many of these modifiers covary with the exposure, leading to much higher risks in some subgroups. These are not theoretical concerns; rather, all these patterns have already been demonstrated in studies of the effects of lead and air pollution. However, recent regulatory impact assessments for these exposures have generally not incorporated these findings. Therefore, differential risk and vulnerability is a critically important but neglected area within risk assessment, and should be incorporated in the future.
AB - Genetic factors, other exposures, individual disease states and allostatic load, psychosocial stress, and socioeconomic position all have the potentialtomodify the response to environmental exposures. Moreover, many of these modifiers covary with the exposure, leading to much higher risks in some subgroups. These are not theoretical concerns; rather, all these patterns have already been demonstrated in studies of the effects of lead and air pollution. However, recent regulatory impact assessments for these exposures have generally not incorporated these findings. Therefore, differential risk and vulnerability is a critically important but neglected area within risk assessment, and should be incorporated in the future.
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U2 - 10.2105/AJPH.2011.300272
DO - 10.2105/AJPH.2011.300272
M3 - Article
C2 - 22021315
AN - SCOPUS:81555220941
SN - 0090-0036
VL - 101
SP - S94-S101
JO - American Journal of Public Health
JF - American Journal of Public Health
IS - SUPPL. 1
ER -