TY - JOUR
T1 - Exploiting metabolic glycoengineering to advance healthcare
AU - Agatemor, Christian
AU - Buettner, Matthew J.
AU - Ariss, Ryan
AU - Muthiah, Keerthana
AU - Saeui, Christopher T.
AU - Yarema, Kevin J.
N1 - Funding Information:
The authors thank the US National Institutes of Health for financial support (grant no. R01 CA112314). C.A. thanks the Natural Sciences and Engineering Research Council of Canada for a postdoctoral fellowship.
Publisher Copyright:
© 2019, Springer Nature Limited.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Metabolic glycoengineering (MGE) is a technique for manipulating cellular metabolism to modulate glycosylation. MGE is used to increase the levels of natural glycans and, more importantly, to install non-natural monosaccharides into glycoconjugates. In this Review, we summarize the chemistry underlying MGE that has been developed over the past three decades and highlight several recent advances that have set the stage for clinical translation. In anticipation of near-term application to human healthcare, we describe emerging efforts to deploy MGE in diverse applications, ranging from the glycoengineering of biotherapeutic proteins and the diagnosis and treatment of complex diseases such as cancer to the development of new immunotherapies.
AB - Metabolic glycoengineering (MGE) is a technique for manipulating cellular metabolism to modulate glycosylation. MGE is used to increase the levels of natural glycans and, more importantly, to install non-natural monosaccharides into glycoconjugates. In this Review, we summarize the chemistry underlying MGE that has been developed over the past three decades and highlight several recent advances that have set the stage for clinical translation. In anticipation of near-term application to human healthcare, we describe emerging efforts to deploy MGE in diverse applications, ranging from the glycoengineering of biotherapeutic proteins and the diagnosis and treatment of complex diseases such as cancer to the development of new immunotherapies.
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U2 - 10.1038/s41570-019-0126-y
DO - 10.1038/s41570-019-0126-y
M3 - Review article
C2 - 31777760
AN - SCOPUS:85074200750
SN - 2397-3358
VL - 3
SP - 605
EP - 620
JO - Nature Reviews Chemistry
JF - Nature Reviews Chemistry
IS - 10
ER -