Exploiting integrative metabolomics to study host–parasite interactions in Plasmodium infections

Maria Nikulkova, Wael Abdrabou, Jane M. Carlton, Youssef Idaghdour

Research output: Contribution to journalReview articlepeer-review


Despite years of research, malaria remains a significant global health burden, with poor diagnostic tests and increasing antimalarial drug resistance challenging diagnosis and treatment. While ‘single-omics’-based approaches have been instrumental in gaining insight into the biology and pathogenicity of the Plasmodium parasite and its interaction with the human host, a more comprehensive understanding of malaria pathogenesis can be achieved through 'multi-omics' approaches. Integrative methods, which combine metabolomics, lipidomics, transcriptomics, and genomics datasets, offer a holistic systems biology approach to studying malaria. This review highlights recent advances, future directions, and challenges involved in using integrative metabolomics approaches to interrogate the interactions between Plasmodium and the human host, paving the way towards targeted antimalaria therapeutics and control intervention methods.

Original languageEnglish (US)
Pages (from-to)313-323
Number of pages11
JournalTrends in parasitology
Issue number4
StatePublished - Apr 2024


  • Plasmodium
  • dual RNA-seq
  • genetics
  • integrative omics
  • malaria
  • metabolomics

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology


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