Experimental validation of a rapid Monte Carlo based micro-CT simulator

A. P. Colijn, Wojtek Zbijewski, A. Sasov, F. J. Beekman

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


We describe a newly developed, accelerated Monte Carlo simulator of a small animal micro-CT scanner. Transmission measurements using aluminium slabs are employed to estimate the spectrum of the x-ray source. The simulator incorporating this spectrum is validated with micro-CT scans of physical water phantoms of various diameters, some containing stainless steel and Teflon rods. Good agreement is found between simulated and real data: normalized error of simulated projections, as compared to the real ones, is typically smaller than 0.05. Also the reconstructions obtained from simulated and real data are found to be similar. Thereafter, effects of scatter are studied using a voxelized software phantom representing a rat body. It is shown that the scatter fraction can reach tens of per cents in specific areas of the body and therefore scatter can significantly affect quantitative accuracy in small animal CT imaging.

Original languageEnglish (US)
Pages (from-to)4321-4333
Number of pages13
JournalPhysics in medicine and biology
Issue number18
StatePublished - Sep 21 2004
Externally publishedYes

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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