Experimental studies of antibiotic associated colitis

J. G. Bartlett

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Clostridium difficile has been implicated as the major cause of antibiotic-associated pseudomembranous colitis. The laboratory diagnostic test of choice is a tissue culture assay that demonstrates the presence of a cytopathic toxin neutralized by antitoxin to Clostridium sordelli. This toxin is found in stools from patients with antibiotic-associated pseudomembranous colitis and in stools from patients with antibiotic-associated diarrhea. Neutralization of toxin by antitoxin to C. sordelli appears to represent antigenic cross-reactivity, since broth cultures of C. difficile also contain a cytopathic toxin neutralized by this toxin. Strains of C. difficile are susceptible to vancomycin and the clinical experience with oral administration of this agent shows promising results.

Original languageEnglish (US)
Pages (from-to)11-15
Number of pages5
JournalScandinavian Journal of Infectious Diseases
Issue numberSUPPL.22
StatePublished - Jan 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • General Immunology and Microbiology
  • Microbiology (medical)
  • Infectious Diseases


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