Experimental retinal neovascularization induced by intravitreal tumors

Daniel Finkelstein, Steven Brem, Arnall Patz, Judah Folkman, Stephen Miller, Chung Ho-Chen

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Adult rabbit retinal vessels underwent neovascularization in response to tumor implantation within the vitreous body. The neovascular response was presumably elicited by the tumor angiogenesis factor (TAF). The response of adult retinal vessels to an angiogenic stimulus raises the possibility that a similar substance may cause retinal neovascularization in humans, and that in normal conditions the vitreous may be able to suppress angiogenic activity.

Original languageEnglish (US)
Pages (from-to)660-664
Number of pages5
JournalAmerican journal of ophthalmology
Issue number5
StatePublished - May 1977

ASJC Scopus subject areas

  • Ophthalmology


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