TY - JOUR
T1 - Experimental human drug self administration
T2 - metholdology and application to the study of sedative abuse
AU - Bigelow, G.
AU - Griffiths, R.
AU - Liebson, I.
PY - 1975/12/1
Y1 - 1975/12/1
N2 - The present study demonstrates that one can establish conditions, within an experimental context, under which human sedative self administration can be observed, measured, and to a degree influenced by prevailing environmental conditions. The model developed, based on previous research with human ethanol self administration, provides for the establishment of stable performance under constant conditions and the sensitivity of that performance to the effects of manipulable experimental variables. The authors' contention is that stability and sensitivity of drug self administration behaviors are an essential prerequisite to systematic experimental analysis of human sedative self administration determinants.
AB - The present study demonstrates that one can establish conditions, within an experimental context, under which human sedative self administration can be observed, measured, and to a degree influenced by prevailing environmental conditions. The model developed, based on previous research with human ethanol self administration, provides for the establishment of stable performance under constant conditions and the sensitivity of that performance to the effects of manipulable experimental variables. The authors' contention is that stability and sensitivity of drug self administration behaviors are an essential prerequisite to systematic experimental analysis of human sedative self administration determinants.
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M3 - Article
C2 - 1223915
AN - SCOPUS:0016790554
SN - 0031-6997
VL - 27
SP - 523
EP - 531
JO - Pharmacological reviews
JF - Pharmacological reviews
IS - 4
ER -