@article{aac69d43bedb4b7fa7d4119bdbea86d0,
title = "Exosomal microrna differential expression in plasma of young adults with chronic mild traumatic brain injury and healthy control",
abstract = "Chronic mild traumatic brain injury (mTBI) has long-term consequences, such as neurological disability, but its pathophysiological mechanism is unknown. Exosomal microRNAs (exo-miRNAs) may be important mediators of molecular and cellular changes involved in persistent symptoms after mTBI. We profiled exosomal microRNAs (exomiRNAs) in plasma from young adults with or without a chronic mTBI to decipher the underlying mechanisms of its long-lasting symptoms after mTBI. We identified 25 significantly dysregulated exomiRNAs in the chronic mTBI group (n = 29, with 4.48 mean years since the last injury) compared to controls (n = 11). These miR-NAs are associated with pathways of neurological disease, organismal injury and abnormalities, and psychological disease. Dysregulation of these plasma exomiRNAs in chronic mTBI may indi-cate that neuronal inflammation can last long after the injury and result in enduring and persistent post-injury symptoms. These findings are useful for diagnosing and treating chronic mTBIs.",
keywords = "ExomiRNA, Exosome, MicroRNA, Mild traumatic brain injury",
author = "Rany Vorn and Maiko Suarez and White, {Jacob C.} and Martin, {Carina A.} and Kim, {Hyung Suk} and Chen Lai and Sijung Yun and Gill, {Jessica M.} and Hyunhwa Lee",
note = "Funding Information: Funding: This research was funded by the School of Nursing of the University of Nevada, Las Vegas (UNLV; 2221-257-554G), the American Psychiatric Nurses Association (APNA; GR009253), and the National Institute of Nursing Research (NINR) Intramural Program. The research was also supported by the UNLV 2017-2020 Top Tier Doctoral Graduate Research Assistantship and the UNLV School of Medicine Medical Student Research Program. Funding Information: Acknowledgments: This study was supported by the UNLV School of Nursing, 2017-2020 UNLV Faculty Top Tier Doctoral Graduate Research Assistantship Program, and the 2019 UNLV School of Medicine Research Program for Medical Students. Blood samples were collected via venipuncture by 2 Registered Nurses, Hannah Greilish and Florence Chipondaminga. The publication fees for this article were supported by the UNLV University Libraries Open Article Fund. Figures 1 and 2 (Top networks) were reprinted from Ingenuity Pathway Analysis under a CC BY 4.0 license, with permission from QIAGEN Silicon Valley, original copyright 2000-2021. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2022",
month = jan,
doi = "10.3390/biomedicines10010036",
language = "English (US)",
volume = "10",
journal = "Biomedicines",
issn = "2227-9059",
publisher = "MDPI AG",
number = "1",
}