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Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas
Yuchen Jiao
, Timothy M. Pawlik
,
Robert A. Anders
,
Florin M. Selaru
, Mirte M. Streppel
, Donald J. Lucas
,
Noushin Niknafs
, Violeta Beleva Guthrie
, Anirban Maitra
,
Pedram Argani
, G. Johan A. Offerhaus
, Juan Carlos Roa
, Lewis R. Roberts
, Gregory J. Gores
, Irinel Popescu
, Sorin T. Alexandrescu
, Simona Dima
, Matteo Fassan
, Michele Simbolo
, Andrea Mafficini
Paola Capelli, Rita T. Lawlor, Andrea Ruzzenente, Alfredo Guglielmi, Giampaolo Tortora, Filippo De Braud, Aldo Scarpa, William Jarnagin, David Klimstra,
Rachel Karchin
,
Victor E. Velculescu
,
Ralph H. Hruban
,
Bert Vogelstein
,
Kenneth W. Kinzler
,
Nickolas Papadopoulos
,
Laura D. Wood
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School of Medicine
Whiting School of Engineering
Howard Hughes Medical Institution
Research output
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Contribution to journal
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Article
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peer-review
397
Scopus citations
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Keyphrases
BRCA1-associated Protein 1 (BAP1)
100%
ARID1A
100%
Intrahepatic Cholangiocarcinoma (iCCA)
100%
Inactivating mutation
100%
Exome Sequencing
100%
PBRM1
100%
Isocitrate Dehydrogenase 1 (IDH1)
50%
Carcinoma
25%
Tumor Protein p53 (TP53)
25%
Metabolic Enzymes
25%
Dysregulated
25%
Chromatin Remodeling
25%
Gallbladder Cancer
25%
Frequent mutation
25%
Chromatin Remodeling Genes
25%
Exomics
25%
Biochemistry, Genetics and Molecular Biology
Chromatin Remodeling
100%
ARID1A
100%
BAP1
100%
Exome Sequencing
100%
PBRM1
100%
Enzyme
50%
IDH1
50%
IDH2
50%
Medicine and Dentistry
Exome Sequencing
100%
Cholangiocarcinoma
100%
Chromatin Remodeling
50%
Carcinoma
25%
Digestant
25%
Gallbladder Carcinoma
25%