Exercise-induced cardiac performance in autoimmune (Type 1) diabetes is associated with a decrease in myocardial diacylglycerol

Rajprasad Loganathan, Lesya Novikova, Igor G. Boulatnikov, Irina V. Smirnova

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


One of the fundamental biochemical defects underlying the complications of diabetic cardiovascular system is elevation of diacylglycerol (DAG) and its effects on protein kinase C (PKC) signaling. It has been noted that exercise training attenuates poor cardiac performance in Type 1 diabetes. However, the role of PKC signaling in exerciseinduced alleviation of cardiac abnormalities in diabetes is not clear. We investigated the possibility that exercise training modulates PKC- βII signaling to elicit its beneficial effects on the diabetic heart. biobreeding diabetic resistant rats, a model reminiscent of Type 1 diabetes in humans, were randomly assigned to four groups: 1) nonexercised nondiabetic (NN); 2) nonexercised diabetic (ND); 3) exercised nondiabetic; and 4) exercised diabetic. Treadmill training was initiated upon the onset of diabetes. At the end of 8 wk, left ventricular (LV) hemodynamic assessment revealed compromised function in ND compared with the NN group. LV myocardial histology revealed increased collagen deposition in ND compared with the NN group, while electron microscopy showed a reduction in the viable mitochondrial fraction. Although the PKC-βII levels and activity were unchanged in the diabetic heart, the DAG levels were increased. With exercise training, the deterioration of LV structure and function in diabetes was attenuated. Notably, improved cardiac performance in training was associated with a decrease in myocardial DAG levels in diabetes. Exercise-induced benefits on cardiac performance in diabetes may be mediated by prevention of an increase in myocardial DAG levels.

Original languageEnglish (US)
Pages (from-to)817-826
Number of pages10
JournalJournal of applied physiology
Issue number5
StatePublished - Sep 1 2012
Externally publishedYes


  • Bio-breeding diabetes resistant rat
  • Diabetic cardiomyopathy
  • Protein kinase C-βII

ASJC Scopus subject areas

  • General Medicine


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