Exercise-induced benefits in individuals with type 1 diabetes

Rajprasad Loganathan, Yvonne M. Searls, Irina V. Smirnova, Lisa Stehno-Bittel

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Individuals with type 1 diabetes are exposed to the pathological effects of chronic hyperglycaemia at an early age. Type 1 diabetes is associated with a variety of complications, including microvascular complications such as diabetic retinopathy, nephropathy, and neuropathy. Conditions like diabetic cardiomyopathy also cause significant mortality and morbidity. The most common macrovascular complications include coronary heart disease, cerebrovascular disease, and peripheral arterial disease. Aerobic exercise is a critical component in the management of individuals with type 1 diabetes. Results from diabetic animal models reveal a variety of cellular mechanisms in response to exercise, producing beneficial effects on diabetic tissue. These results suggest that exercise training leads to improved tissue function by targeting specific adaptive mechanisms in diabetes, especially when initiated at the early stages of the disease. Hence, long-term aerobic exercises produces beneficial effects beyond insulin and nutrition therapy alone, as indicated by epidemiological and clinical studies in type 1 diabetics.

Original languageEnglish (US)
Pages (from-to)77-89
Number of pages13
JournalPhysical Therapy Reviews
Issue number2
StatePublished - Jun 1 2006
Externally publishedYes



ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation


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