Exercise and the Endogenous Opioids

Steven R. Gambert, Thad C. Hagen, Thomas L. Garthwaite, Edmund H. Duthie, Daniel J. Mccarty, Lorin M. Hawley, Gail E. Butterfield, Peter A. Farrell, Daniel B. Carr, Beverly A. Bullen, Gary S. Skrinar, Michael A. Arnold, Michael Rosenblatt, Inese Z. Beitins, Joseph B. Martin, Janet W. Mcarthur

Research output: Contribution to journalLetterpeer-review

31 Scopus citations


To the Editor: We read with great interest the paper by Carr et al. in the September 3 issue1 on the relation between exercise and β-endorphin secretion in women. We have previously reported a study in which five untrained subjects (four men and one woman) 26 to 35 years old ran for 20 minutes on a treadmill at a speed that was adjusted to maintain the heart rate at 80 per cent of maximum.2 Plasma samples were obtained before and after exercise, and β-endorphin immunoreactivity was measured by radioimmunoassay. There was a 440 per cent mean increase in circulating β-endorphin.

Original languageEnglish (US)
Pages (from-to)1590-1592
Number of pages3
JournalNew England Journal of Medicine
Issue number26
StatePublished - Dec 24 1981
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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