@article{eae72b509a6745cfbd9be9d1553d7ff6,
title = "Examining the causal mediating role of brain pathology on the relationship between diabetes and cognitive impairment: the Cardiovascular Health Study",
abstract = "The paper examines whether diabetes mellitus leads to incident mild cognitive impairment and dementia through brain hypoperfusion and white matter disease. We performed inverse odds ratio weighted causal mediation analyses to decompose the effect of diabetes on cognitive impairment into direct and indirect effects, and we found that approximately a third of the total effect of diabetes is mediated through vascular-related brain pathology. Our findings lend support for a common aetiological hypothesis regarding incident cognitive impairment, which is that diabetes increases the risk of clinical cognitive impairment in part by impacting the vasculature of the brain.",
keywords = "Alzheimer's disease, Causal inference, Causal mediation analysis, Cognitive neuroscience, Public health",
author = "Andrews, {Ryan M.} and Ilya Shpitser and Oscar Lopez and Longstreth, {William T.} and Chaves, {Paulo H.M.} and Lewis Kuller and Carlson, {Michelle C.}",
note = "Funding Information: This research was supported by contracts HHSN268201200036C, HHSN268200800007C, HHSN268201800001C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083 and N01HC85086, and grants U01HL080295 and U01HL130114 from the National Heart, Lung, and Blood Institute, with an additional contribution from the National Institute of Neurological Disorders and Stroke. Additional support was provided by grant R01AG023629 from the National Institute on Aging. A full list of principal CHS investigators and institutions can be found at CHSNHLBI.org. Additional research support was provided by grants T32AG027668 (to RMA), R01AI127271-01A1 (to IS), Office for Naval Research grant N00014-18-1-2760 (to IS) and National Science Foundation grants 19-571 and 1939675 (to IS). The content of this work is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Funding Information: This research was supported by contracts HHSN268201200036C, HHSN268200800007C, HHSN268201800001C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083 and N01HC85086, and grants U01HL080295 and U01HL130114 from the National Heart, Lung, and Blood Institute, with an additional contribution from the National Institute of Neurological Disorders and Stroke. Additional support was provided by grant R01AG023629 from the National Institute on Aging. A full list of principal CHS investigators and institutions can be found at . CHSNHLBI.org Funding Information: Additional research support was provided by grants T32AG027668 (to RMA), R01AI127271‐01A1 (to IS), Office for Naval Research grant N00014‐18‐1‐2760 (to IS) and National Science Foundation grants 19‐571 and 1939675 (to IS). Publisher Copyright: {\textcopyright} 2020 The Authors Journal of the Royal Statistical Society: Series A (Statistics in Society) published by John Wiley & Sons Ltd on behalf of Royal Statistical Society",
year = "2020",
month = oct,
day = "1",
doi = "10.1111/rssa.12570",
language = "English (US)",
volume = "183",
pages = "1705--1726",
journal = "Journal of the Royal Statistical Society. Series A: Statistics in Society",
issn = "0964-1998",
publisher = "Wiley-Blackwell",
number = "4",
}