Exaggerated vasopressor response to exercise and cerebral blood flow velocity

Vernon Bond; Richard M. Millis; Alfonso Campbell; Jules Harrell; Kim L. Goring; Inez Reeves; Sheree M. Johnson; Richard G. Adams

doi:10.3109/10641963.2012.665537

Exaggerated vasopressor response to exercise and cerebral blood flow velocity

Vernon Bond, Richard M. Millis, Alfonso Campbell, Jules Harrell, Kim L. Goring, Inez Reeves, Sheree M. Johnson, Richard G. Adams

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We studied 10 young adults, normotensive at rest, comprising a control group (n 5) with normal blood pressure responsiveness to exercise and an experimental group exhibiting greater percentage of body fat and body mass index (BMI) than the controls, with exaggerated blood pressure (vasopressor) responsiveness to exercise (EEBPR) (n = 5). Lower absolute and varying oxygen consumption/body weight normalized units of middle cerebral arterial blood flow velocity (MCAV) were found during exercise in the experimental group (P <.01). These findings support the hypothesis that the combination of EEBPR and high BMI is associated with low MCAV that may put such individuals at risk for cerebral hypoperfusion and cognitive deficits.

Original language	English (US)
Pages (from-to)	370-376
Number of pages	7
Journal	Clinical and Experimental Hypertension
Volume	34
Issue number	5
DOIs	https://doi.org/10.3109/10641963.2012.665537
State	Published - Aug 2012
Externally published	Yes

Keywords

Blood flow velocity
Cerebral blood flow
Exercise
Humans
Hypertension
Middle cerebral artery

ASJC Scopus subject areas

Internal Medicine
Physiology

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10.3109/10641963.2012.665537

Cite this

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abstract = "We studied 10 young adults, normotensive at rest, comprising a control group (n 5) with normal blood pressure responsiveness to exercise and an experimental group exhibiting greater percentage of body fat and body mass index (BMI) than the controls, with exaggerated blood pressure (vasopressor) responsiveness to exercise (EEBPR) (n = 5). Lower absolute and varying oxygen consumption/body weight normalized units of middle cerebral arterial blood flow velocity (MCAV) were found during exercise in the experimental group (P <.01). These findings support the hypothesis that the combination of EEBPR and high BMI is associated with low MCAV that may put such individuals at risk for cerebral hypoperfusion and cognitive deficits.",

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AU - Bond, Vernon

AU - Millis, Richard M.

AU - Campbell, Alfonso

AU - Harrell, Jules

AU - Goring, Kim L.

AU - Reeves, Inez

AU - Johnson, Sheree M.

AU - Adams, Richard G.

PY - 2012/8

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KW - Cerebral blood flow

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KW - Hypertension

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Exaggerated vasopressor response to exercise and cerebral blood flow velocity

Abstract

Keywords

ASJC Scopus subject areas

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