Evolving adaptive immunity

Geoffrey A. Lovely; Ranjan Sen

doi:10.1101/gad.281014.116

Evolving adaptive immunity

Geoffrey A. Lovely, Ranjan Sen

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Generation of a diverse repertoire of antigen receptor specificities via DNA recombination underpins adaptive immunity. In this issue of Genes &Development, Carmona and colleagues (pp. 909–917) provide novel insights into the origin and function of recombination-activating gene 1 (RAG1) and RAG2, the lymphocyte-specific components of the recombinase involved in the process.

Original language	English (US)
Pages (from-to)	873-875
Number of pages	3
Journal	Genes & development
Volume	30
Issue number	8
DOIs	https://doi.org/10.1101/gad.281014.116
State	Published - Apr 15 2016
Externally published	Yes

Keywords

Evolution
RAG
Transib
Transposition
V(D)J recombination

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1101/gad.281014.116

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abstract = "Generation of a diverse repertoire of antigen receptor specificities via DNA recombination underpins adaptive immunity. In this issue of Genes &Development, Carmona and colleagues (pp. 909–917) provide novel insights into the origin and function of recombination-activating gene 1 (RAG1) and RAG2, the lymphocyte-specific components of the recombinase involved in the process.",

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author = "Lovely, {Geoffrey A.} and Ranjan Sen",

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AU - Sen, Ranjan

PY - 2016/4/15

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AB - Generation of a diverse repertoire of antigen receptor specificities via DNA recombination underpins adaptive immunity. In this issue of Genes &Development, Carmona and colleagues (pp. 909–917) provide novel insights into the origin and function of recombination-activating gene 1 (RAG1) and RAG2, the lymphocyte-specific components of the recombinase involved in the process.

KW - Evolution

KW - RAG

KW - Transib

KW - Transposition

KW - V(D)J recombination

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Evolving adaptive immunity

Abstract

Keywords

ASJC Scopus subject areas

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