Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes

Robert M. Waterhouse, Evgenia V. Kriventseva, Stephan Meister, Zhiyong Xi, Kanwal S. Alvarez, Lyric C. Bartholomay, Carolina Barillas-Mury, Guowu Bian, Stephanie Blandin, Bruce M. Christensen, Yuemei Dong, Haobo Jiang, Michael R. Kanost, Anastasios C. Koutsos, Elena A. Levashina, Jianyong Li, Petros Ligoxygakis, Robert M. MacCallum, George F. Mayhew, Antonio MendesKristin Michel, Mike A. Osta, Susan Paskewitz, Woon Shin Sang, Dina Vlachou, Lihui Wang, Qi Wei, Liangbiao Zheng, Zhen Zou, David W. Severson, Alexander S. Raikhel, Fotis C. Kafatos, George Dimopoulos, Evgeny M. Zdobnov, George K. Christophides

Research output: Contribution to journalArticlepeer-review

418 Scopus citations


Mosquitoes are vectors of parasitic and viral diseases of immense importance for public health. The acquisition of the genome sequence of the yellow fever and Dengue vector, Aedes aegypti (Aa), has enabled a comparative phylogenomic analysis of the insect immune repertoire: in Aa, the malaria vector Anopheles gambiae (Ag), and the fruit fly Drosophila melanogaster (Dm). Analysis of immune signaling pathways and response modules reveals both conservative and rapidly evolving features associated with different functional gene categories and particular aspects of immune reactions. These dynamics reflect in part continuous readjustment between accommodation and rejection of pathogens and suggest how innate immunity may have evolved.

Original languageEnglish (US)
Pages (from-to)1738-1743
Number of pages6
Issue number5832
StatePublished - Jun 22 2007

ASJC Scopus subject areas

  • General


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