TY - JOUR
T1 - Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36
AU - Means, Terry K.
AU - Mylonakis, Eleftherios
AU - Tampakakis, Emmanouil
AU - Colvin, Richard A.
AU - Seung, Edward
AU - Puckett, Lindsay
AU - Tai, Melissa F.
AU - Stewart, Cameron R.
AU - Pukkila-Worley, Read
AU - Hickman, Suzanne E.
AU - Moore, Kathryn J.
AU - Calderwood, Stephen B.
AU - Hacohen, Nir
AU - Luster, Andrew D.
AU - Khoury, Joseph El
PY - 2009/3/16
Y1 - 2009/3/16
N2 - Receptors involved in innate immunity to fungal pathogens have not been fully elucidated. We show that the Caenorhabditis elegans receptors CED-1 and C03F11.3, and their mammalian orthologues, the scavenger receptors SCARF1 and CD36, mediate host defense against two prototypic fungal pathogens, Cryptococcus neoformans and Candida albicans. CED-1 and C03F11.1 mediated antimicrobial peptide production and were necessary for nematode survival after C. neoformans infection. SCARF1 and CD36 mediated cytokine production and were required for macrophage binding to C. neoformans, and control of the infection in mice. Binding of these pathogens to SCARF1 and CD36 was β-glucan dependent. Thus, CED-1/SCARF1 and C03F11.3/CD36 are β-glucan binding receptors and define an evolutionarily conserved pathway for the innate sensing of fungal pathogens.
AB - Receptors involved in innate immunity to fungal pathogens have not been fully elucidated. We show that the Caenorhabditis elegans receptors CED-1 and C03F11.3, and their mammalian orthologues, the scavenger receptors SCARF1 and CD36, mediate host defense against two prototypic fungal pathogens, Cryptococcus neoformans and Candida albicans. CED-1 and C03F11.1 mediated antimicrobial peptide production and were necessary for nematode survival after C. neoformans infection. SCARF1 and CD36 mediated cytokine production and were required for macrophage binding to C. neoformans, and control of the infection in mice. Binding of these pathogens to SCARF1 and CD36 was β-glucan dependent. Thus, CED-1/SCARF1 and C03F11.3/CD36 are β-glucan binding receptors and define an evolutionarily conserved pathway for the innate sensing of fungal pathogens.
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U2 - 10.1084/jem.20082109
DO - 10.1084/jem.20082109
M3 - Article
C2 - 19237602
AN - SCOPUS:63449138494
SN - 0022-1007
VL - 206
SP - 637
EP - 653
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 3
ER -