Evolutionarily conserved network properties of intrinsically disordered proteins

Nivedita Rangarajan, Prakash Kulkarni, Sridhar Hannenhalli

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Background: Intrinsically disordered proteins (IDPs) lack a stable tertiary structure in isolation. Remarkably, however, a substantial portion of IDPs undergo disorder-to-order transitions upon binding to their cognate partners. Structural flexibility and binding plasticity enable IDPs to interact with a broad range of partners. However, the broader network properties that could provide additional insights into the functional role of IDPs are not known. Results: Here, we report the first comprehensive survey of network properties of IDP-induced subnetworks in multiple species from yeast to human. Our results show that IDPs exhibit greater-than-expected modularity and are connected to the rest of the protein interaction network (PIN) via proteins that exhibit the highest betweenness centrality and connect to fewer-than-expected IDP communities, suggesting that they form critical communication links from IDP modules to the rest of the PIN. Moreover, we found that IDPs are enriched at the top level of regulatory hierarchy. Conclusion: Overall, our analyses reveal coherent and remarkably conserved IDP-centric network properties, namely, modularity in IDP-induced network and a layer of critical nodes connecting IDPs with the rest of the PIN.

Original languageEnglish (US)
Article numbere0126729
JournalPloS one
Issue number5
StatePublished - May 14 2015

ASJC Scopus subject areas

  • General


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