TY - JOUR
T1 - Evolution of ventricular hypertrophy and myocardial mechanics in physiological and pathological hypertrophy
AU - Yalçin, Fatih
AU - Kucukler, Nagehan
AU - Cingolani, Oscar
AU - Mbiyangandu, Blaid
AU - Sorensen, Lars
AU - Pinherio, Aurelio
AU - Abraham, Roselle
AU - Abraham, Theodore P.
N1 - Funding Information:
The study was partially supported by National Heart, Lung, and Blood Institute Grant HL-98046. F. Yalcin was supported by a Fulbright scholarship.
Publisher Copyright:
Copyright © 2019 the American Physiological Society
PY - 2019/2
Y1 - 2019/2
N2 - Left ventricular hypertrophy (LVH) is an adaptive response to physiological or pathological stimuli, and distinguishing between the two has obvious clinical implications. However, asymmetric septal hypertrophy and preserved cardiac function are noted in early stages in both cases. We characterized the early anatomic and functional changes in a mouse model of physiological and pathological stress using serial echocardiography-based morphometry and tissue velocity imaging. Weight-matched CF-1 male mice were separated into Controls (n 10), treadmill Exercise 1 h daily for 5 days/wk (n 7), and transverse aortic constriction (TAC, n 7). Hypertrophy was noted first in the left ventricle basal septum compared with other segments in Exercise (0.84 0.02 vs. 0.79 0.03 mm, P 0.03) and TAC (0.86 0.05 vs. 0.77 0.04 mm, P 0.02) at 4 and 3 wk, respectively. At 8 wk, eccentric LVH was noted in Exercise and concentric LVH in TAC. Septal E/E= ratio increased in TAC (32.6 3.7 vs. 37 6.2, P 0.002) compared with the Controls and Exercise (32.3 5.2 vs. 32.8 3.8 and 31.2 4.9 vs. 28.2 5.0, respectively, nonsignificant for both). Septal s= decreased in TAC (21 3.6 vs. 17 4.2 mm/s, P 0.04) but increased in Exercise (19.6 4.1 vs. 29.2 2.3 mm/s, P 0.001) and was unchanged in Controls (20.1 4.2 vs. 20.9 5.1 mm/s, nonsignificant). With similar asymmetric septal hypertrophy and normal global function during the first 4 – 8 wk of pathological and physiological stress, there is an early marginal increase with subsequent decrease in systolic tissue velocity in pathological but early and progressive increase in physiological hypertrophy. Tissue velocities may help adjudicate between these two states when there are no overt anatomic or functional differences.
AB - Left ventricular hypertrophy (LVH) is an adaptive response to physiological or pathological stimuli, and distinguishing between the two has obvious clinical implications. However, asymmetric septal hypertrophy and preserved cardiac function are noted in early stages in both cases. We characterized the early anatomic and functional changes in a mouse model of physiological and pathological stress using serial echocardiography-based morphometry and tissue velocity imaging. Weight-matched CF-1 male mice were separated into Controls (n 10), treadmill Exercise 1 h daily for 5 days/wk (n 7), and transverse aortic constriction (TAC, n 7). Hypertrophy was noted first in the left ventricle basal septum compared with other segments in Exercise (0.84 0.02 vs. 0.79 0.03 mm, P 0.03) and TAC (0.86 0.05 vs. 0.77 0.04 mm, P 0.02) at 4 and 3 wk, respectively. At 8 wk, eccentric LVH was noted in Exercise and concentric LVH in TAC. Septal E/E= ratio increased in TAC (32.6 3.7 vs. 37 6.2, P 0.002) compared with the Controls and Exercise (32.3 5.2 vs. 32.8 3.8 and 31.2 4.9 vs. 28.2 5.0, respectively, nonsignificant for both). Septal s= decreased in TAC (21 3.6 vs. 17 4.2 mm/s, P 0.04) but increased in Exercise (19.6 4.1 vs. 29.2 2.3 mm/s, P 0.001) and was unchanged in Controls (20.1 4.2 vs. 20.9 5.1 mm/s, nonsignificant). With similar asymmetric septal hypertrophy and normal global function during the first 4 – 8 wk of pathological and physiological stress, there is an early marginal increase with subsequent decrease in systolic tissue velocity in pathological but early and progressive increase in physiological hypertrophy. Tissue velocities may help adjudicate between these two states when there are no overt anatomic or functional differences.
KW - Basal septal hypertrophy
KW - Early imaging biomarker
KW - Left ventricular remodeling
KW - Microimaging
KW - Pathological stress
KW - Physiological stress
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U2 - 10.1152/japplphysiol.00199.2016
DO - 10.1152/japplphysiol.00199.2016
M3 - Article
C2 - 29357486
AN - SCOPUS:85054018611
SN - 8750-7587
VL - 126
SP - 354
EP - 362
JO - Journal of applied physiology
JF - Journal of applied physiology
IS - 2
ER -