Evolution of thrombectomy approaches and devices for acute stroke: A technical review

Alejandro M. Spiotta, M. Imran Chaudry, Ferdinand K. Hui, Raymond D. Turner, Ryan T. Kellogg, Aquilla S. Turk

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations


While intravenous administration of tissue plasminogen activator (tPA) remains the only FDA-approved treatment modality for acute ischemic stroke, many patients do not meet the criteria for intravenous tPA and are offered intra-arterial therapy. Rapid advances in devices and approaches have marked the evolution of thrombectomy over the past decade from rudimentary mechanical disruption, followed by intra-arterial thrombolytic infusions to increasingly effective thrombectomy devices. We review the critical advancements in thrombectomy technique that have evolved and the key anatomic and technical challenges they address, from first-generation Merci retrieval systems to second-generation Penumbra aspiration systems and third-generation stent retrievers, as well as nuances of their uses to maximize their effectiveness. We also highlight more recent advances that offer patients hope for more expedient vessel recanalization.

Original languageEnglish (US)
Pages (from-to)2-7
Number of pages6
JournalJournal of neurointerventional surgery
Issue number1
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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