Evolution of molecular targets for antipsychotic therapy

S. Marenco, D. R. Weinberger

Research output: Contribution to journalReview articlepeer-review


The evolution of molecular targets for the treatment of psychosis is briefly summarized. Hypotheses regarding the effectiveness of medications for schizophrenia are also reviewed. While approaches that target dopamine receptors are still the sinequa-non of effective treatment, a considerable evolution has occurred with the introduction of atypical neuroleptics and, lately, of aripiprazole, in terms how how these drugs interact with dopamine receptors. Moreover, new approaches are appearing on the horizon that will target other receptor systems, especially glutamate transmission.

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalItalian Journal of Psychopathology
Issue number1
StatePublished - Mar 1 2003
Externally publishedYes


  • Antipsychotic drugs
  • Dopamine
  • Glutamate
  • Molecular targets
  • Psychosis

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health


Dive into the research topics of 'Evolution of molecular targets for antipsychotic therapy'. Together they form a unique fingerprint.

Cite this