TY - JOUR
T1 - Evidence of slow maturation of the superior longitudinal fasciculus in early childhood by diffusion tensor imaging
AU - Zhang, Jiangyang
AU - Evans, Alan
AU - Hermoye, Laurent
AU - Lee, Seung Koo
AU - Wakana, Setsu
AU - Zhang, Weihong
AU - Donohue, Pamela
AU - Miller, Michael I.
AU - Huang, Hao
AU - Wang, Xiaoqing
AU - van Zijl, Peter C.M.
AU - Mori, Susumu
PY - 2007/11/1
Y1 - 2007/11/1
N2 - While the majority of axonal organization is established by birth in mammalian brains, axonal wiring and pruning processes, as well as myelination, are known to extend to the postnatal periods, where environmental stimuli often play a major role. Normal axonal and myelin development of individual white matter tracts of human in this period is poorly understood and may have a major role in cognitive development of human. In this study, we applied diffusion tensor imaging and normalization-based population analyses to 44 preteen children and 30 adult images. We observed highly significant changes of fiber orientations at regions that correspond to the superior longitudinal fasciculus during the first 5 years. The result is attributed to slow axonal and/or myelin maturation of this tract, which is believed to be involved in language functions.
AB - While the majority of axonal organization is established by birth in mammalian brains, axonal wiring and pruning processes, as well as myelination, are known to extend to the postnatal periods, where environmental stimuli often play a major role. Normal axonal and myelin development of individual white matter tracts of human in this period is poorly understood and may have a major role in cognitive development of human. In this study, we applied diffusion tensor imaging and normalization-based population analyses to 44 preteen children and 30 adult images. We observed highly significant changes of fiber orientations at regions that correspond to the superior longitudinal fasciculus during the first 5 years. The result is attributed to slow axonal and/or myelin maturation of this tract, which is believed to be involved in language functions.
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U2 - 10.1016/j.neuroimage.2007.07.033
DO - 10.1016/j.neuroimage.2007.07.033
M3 - Article
C2 - 17826183
AN - SCOPUS:34948815563
SN - 1053-8119
VL - 38
SP - 239
EP - 247
JO - NeuroImage
JF - NeuroImage
IS - 2
ER -