Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma

Jeffrey M. Trent, P. Meltzer, M. Rosenblum, G. Harsh, K. Kinzler, R. Mashal, A. Feinberg, B. Vogelstein

Research output: Contribution to journalArticlepeer-review

139 Scopus citations


Amplified cellular genes are frequently manifested in one of two cytologically recognizable forms, double minutes or homogeneously staining regions. Additionally, evidence is accumulating that aberrant expression of cellular genes (including oncogenes) may be mediated by gene amplification. We now describe the amplification and expression of the cellular oncogene c-myc in double-minute-containing cells from a patient with glioblastoma multiforme, and we have shown that the amplification is associated with rearrangement of the c-myc gene. This finding further supports the common association of the myc gene family in neurogenic tumors and provides evidence of myc gene amplification in human brain cancer.

Original languageEnglish (US)
Pages (from-to)470-473
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number2
StatePublished - 1986

ASJC Scopus subject areas

  • General


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