Evidence for linkage of chromosome 12q15-q24.1 markers to high total serum IgE concentrations in children of the German Multicenter Allergy Study

Renate Nickel; Ulrich Wahn; Nobuyuki Hizawa; Nancy Maestri; David L. Duffy; Kathleen C. Barnes; Kirsten Beyer; Johannes Forster; Renate Bergmann; Fred Zepp; Volker Wahn; David G. Marsh

doi:10.1006/geno.1997.5013

Evidence for linkage of chromosome 12q15-q24.1 markers to high total serum IgE concentrations in children of the German Multicenter Allergy Study

Renate Nickel, Ulrich Wahn, Nobuyuki Hizawa, Nancy Maestri, David L. Duffy, Kathleen C. Barnes, Kirsten Beyer, Johannes Forster, Renate Bergmann, Fred Zepp, Volker Wahn, David G. Marsh

School of Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

Linkage of asthma and high total serum IgE levels to chromosome 12q15- q24.1 has been recently described. To evaluate this region further in regard to total IgE responsiveness, we genotyped 52 unrelated German children with persistently 'high' total serum IgE (selected from a noninterventional prospective multicenter cohort study) and their parents. We carefully defined a most extreme IgE phenotype and analyzed it as a dichotomous trait. We tested for lineage between high total IgE concentrations and nine polymorphic microsatellite markers on chromosome 12q15-q24.1 using the transmission/disequilibrium test. Evidence for lineage and allelic association for high total IgE was observed for four markers in this region. This study demonstrates the value of using extreme phenotypes in genetic analysis of a complex quantitative trait.

Original language	English (US)
Pages (from-to)	159-162
Number of pages	4
Journal	Genomics
Volume	46
Issue number	1
DOIs	https://doi.org/10.1006/geno.1997.5013
State	Published - Nov 15 1997

ASJC Scopus subject areas

Genetics

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title = "Evidence for linkage of chromosome 12q15-q24.1 markers to high total serum IgE concentrations in children of the German Multicenter Allergy Study",

abstract = "Linkage of asthma and high total serum IgE levels to chromosome 12q15- q24.1 has been recently described. To evaluate this region further in regard to total IgE responsiveness, we genotyped 52 unrelated German children with persistently 'high' total serum IgE (selected from a noninterventional prospective multicenter cohort study) and their parents. We carefully defined a most extreme IgE phenotype and analyzed it as a dichotomous trait. We tested for lineage between high total IgE concentrations and nine polymorphic microsatellite markers on chromosome 12q15-q24.1 using the transmission/disequilibrium test. Evidence for lineage and allelic association for high total IgE was observed for four markers in this region. This study demonstrates the value of using extreme phenotypes in genetic analysis of a complex quantitative trait.",

author = "Renate Nickel and Ulrich Wahn and Nobuyuki Hizawa and Nancy Maestri and Duffy, {David L.} and Barnes, {Kathleen C.} and Kirsten Beyer and Johannes Forster and Renate Bergmann and Fred Zepp and Volker Wahn and Marsh, {David G.}",

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T1 - Evidence for linkage of chromosome 12q15-q24.1 markers to high total serum IgE concentrations in children of the German Multicenter Allergy Study

AU - Nickel, Renate

AU - Wahn, Ulrich

AU - Hizawa, Nobuyuki

AU - Maestri, Nancy

AU - Duffy, David L.

AU - Barnes, Kathleen C.

AU - Beyer, Kirsten

AU - Forster, Johannes

AU - Bergmann, Renate

AU - Zepp, Fred

AU - Wahn, Volker

AU - Marsh, David G.

PY - 1997/11/15

Y1 - 1997/11/15

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AB - Linkage of asthma and high total serum IgE levels to chromosome 12q15- q24.1 has been recently described. To evaluate this region further in regard to total IgE responsiveness, we genotyped 52 unrelated German children with persistently 'high' total serum IgE (selected from a noninterventional prospective multicenter cohort study) and their parents. We carefully defined a most extreme IgE phenotype and analyzed it as a dichotomous trait. We tested for lineage between high total IgE concentrations and nine polymorphic microsatellite markers on chromosome 12q15-q24.1 using the transmission/disequilibrium test. Evidence for lineage and allelic association for high total IgE was observed for four markers in this region. This study demonstrates the value of using extreme phenotypes in genetic analysis of a complex quantitative trait.

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Evidence for linkage of chromosome 12q15-q24.1 markers to high total serum IgE concentrations in children of the German Multicenter Allergy Study

Abstract

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