Evaluation of the photo-degradation of Alzheimer's amyloid fibrils with a label-free approach

Tianke Wang; Liwei Zhang; Jie Wang; Yonghai Feng; Enquan Xu; Xiaobo Mao; Lei Liu

doi:10.1039/c8cc07164k

Evaluation of the photo-degradation of Alzheimer's amyloid fibrils with a label-free approach

Tianke Wang, Liwei Zhang, Jie Wang, Yonghai Feng, Enquan Xu, Xiaobo Mao, Lei Liu

School of Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Degradation of amyloid-β (Aβ) aggregates has been considered as an attractive therapeutic and preventive strategy against Alzheimer's disease (AD). However, an in situ, real-time, and label-free technique is still lacking to understand the degradation process of Aβ aggregates. In this work, we developed a novel method to quantitatively evaluate the degradation of Aβ fibrils by photoactive meso-tetra(4-sulfonatophenyl)porphyrin under UV irradiation with quartz crystal microbalance (QCM).

Original language	English (US)
Pages (from-to)	13084-13087
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	93
DOIs	https://doi.org/10.1039/c8cc07164k
State	Published - 2018

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "Degradation of amyloid-β (Aβ) aggregates has been considered as an attractive therapeutic and preventive strategy against Alzheimer's disease (AD). However, an in situ, real-time, and label-free technique is still lacking to understand the degradation process of Aβ aggregates. In this work, we developed a novel method to quantitatively evaluate the degradation of Aβ fibrils by photoactive meso-tetra(4-sulfonatophenyl)porphyrin under UV irradiation with quartz crystal microbalance (QCM).",

author = "Tianke Wang and Liwei Zhang and Jie Wang and Yonghai Feng and Enquan Xu and Xiaobo Mao and Lei Liu",

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AU - Wang, Tianke

AU - Zhang, Liwei

AU - Wang, Jie

AU - Feng, Yonghai

AU - Xu, Enquan

AU - Mao, Xiaobo

AU - Liu, Lei

PY - 2018

Y1 - 2018

N2 - Degradation of amyloid-β (Aβ) aggregates has been considered as an attractive therapeutic and preventive strategy against Alzheimer's disease (AD). However, an in situ, real-time, and label-free technique is still lacking to understand the degradation process of Aβ aggregates. In this work, we developed a novel method to quantitatively evaluate the degradation of Aβ fibrils by photoactive meso-tetra(4-sulfonatophenyl)porphyrin under UV irradiation with quartz crystal microbalance (QCM).

AB - Degradation of amyloid-β (Aβ) aggregates has been considered as an attractive therapeutic and preventive strategy against Alzheimer's disease (AD). However, an in situ, real-time, and label-free technique is still lacking to understand the degradation process of Aβ aggregates. In this work, we developed a novel method to quantitatively evaluate the degradation of Aβ fibrils by photoactive meso-tetra(4-sulfonatophenyl)porphyrin under UV irradiation with quartz crystal microbalance (QCM).

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JO - Chemical Communications

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ER -

Evaluation of the photo-degradation of Alzheimer's amyloid fibrils with a label-free approach

Abstract

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