Evaluation of myocardial defect detection between parallel-hole and fan-beam SPECT using the hotelling trace

S. D. Wollenweber, B. M.W. Tsui, D. S. Lalush', E. C. Frey, G. T. Gullberg

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The objective of this study was to implement the Hotelling trace (HT) to evaluate the potential increase in defect detection in myocardial SPECT using high-resolution fan-beam (HRF) versus parallel-hole (HRP) collimation and compare results to a previously reported human observer study [1]. Projection data from the 3D MCAT torso phantom were simulated including the effects of attenuation, collimator-detector response blurring and scatter. Poisson noise fluctuations were then simulated. The HRP and HRF collimators had the same spatial resolution at 20 cm. The total counts in the projection data sets were proportional to the detection efficiencies of the collimators and on the order of that found in clinical Tc-99m studies. In six left-ventricular defect locations, the HT found for HRF was superior to that for HRP collimation. For HRF collimation, the HT was calculated for reconstructed images using 64×64, 128×128 and 192×192 grid sizes. The results demonstrate substantial improvement in myocardial defect detection when the grid size was increased from 64×64 to 128×128 and slight improvement from 128×128 to 192×192. Also, the performance of the Hotelling observer in terms of the HT at the different grid sizes correlates at better than 0.95 to that found in human observers in a previously reported observer experiment and ROC study.

Original languageEnglish (US)
Pages (from-to)2205-2210
Number of pages6
JournalIEEE Transactions on Nuclear Science
Issue number4 PART 2
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Nuclear Energy and Engineering
  • Electrical and Electronic Engineering


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