Evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal SARS-CoV-2 infection in early and late gestation

Elizabeth S. Taglauer, Yashoda Dhole, Jeffery Boateng, Jennifer Snyder-Cappione, Samantha E. Parker, Katherine Clarke, Lillian Juttukonda, Jean Devera, Jessica Hunnewell, Elizabeth Barnett, Hongpeng Jia, Christina Yarrington, Vishakha Sabharwal, Elisha M. Wachman

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: SARS-CoV-2 infection induces significant inflammatory cytokine production in adults, but infant cytokine signatures in pregnancies affected by maternal SARS-CoV-2 are less well characterized. We aimed to evaluate cytokine profiles of mothers and their infants following COVID-19 in pregnancy. Study design: Serum samples at delivery from 31 mother-infant dyads with maternal SARS-CoV-2 infection in pregnancy (COVID) were examined in comparison to 29 control dyads (Control). Samples were evaluated using a 13-plex cytokine assay. Results: In comparison with controls, interleukin (IL)-6 and interferon gamma-induced protein 10 (IP-10) were higher in COVID maternal and infant samples (p < 0.05) and IL-8 uniquely elevated in COVID infant samples (p < 0.05). Significant elevations in IL-6, IP-10, and IL-8 were found among both early (1st/2nd Trimester) and late (3rd Trimester) maternal SARS-CoV-2 infections. Conclusions: Maternal SARS-CoV-2 infections throughout gestation are associated with increased maternal and infant inflammatory cytokines at birth with potential to impact long-term infant health.

Original languageEnglish (US)
Pages (from-to)1319-1327
Number of pages9
JournalJournal of Perinatology
Volume42
Issue number10
DOIs
StatePublished - Oct 2022

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

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