@article{1968d7e438294b68a86f98d7e611d6ec,
title = "Evaluation of coxsackievirus infection in children with human immunodeficiency virus type 1-associated cardiomyopathy",
abstract = "In a matched case-control study of the association between coxsackieviruses and cardiac impairment, 24 human immunodeficiency virus (HIV) type 1-infected children with cardiac impairment were compared with 24 HIV-1-infected control subjects. Serologic evidence of coxsackievirus infection was present in all children, with no significant difference in geometric mean antibody titers between case patients and control subjects. Conditional logistic regression to test for an association between coxsackievirus antibody titer and the presence or absence of cardiac impairment, by any indicator, showed an odds ratio of 1.11 (95% confidence interval, 0.58-2.10; P = .75), indicating no association between coxsackievirus infection and cardiac impairment. Coxsackievirus antibody titers correlated positively with total IgG levels in nonrapid progressors but not in rapid progressors. Paired serum samples taken before and after diagnosis of cardiac impairment in 5 patients showed no evidence of intervening coxsackievirus infection. These results do not identify a causal role for coxsackieviruses for cardiomyopathy in HIV-1-infected children.",
author = "{Pediatric Pulmonary and Cardiovascular Complications of HIV-1 Infection Study Group} and Jenson, {Hal B.} and Gauntt, {Charles J.} and Easley, {Kirk A.} and Jane Pitt and Lipshultz, {Steven E.} and {Mc Intosh}, Kenneth and Shearer, {William T.} and Anthony Kalica and Elaine Sloand and George Sopko and Margaret Wu and Robert Mellins and William Shearer and Gail Demmler and Linda Davis and Debra Mooneyham and Teresa Tonsberg and Steven Lipshultz and {Mc Intosh}, Kenneth and Janice Hunter and Ellen Cooper and Suzanne Steinbach and Karen Lewis and Meyer Kattan and David MHodes and Diane Carp and Stephen Heaton and Worth, {Mary Ann} and Karen Lewis and Robert Mellins and Kim Geromanos and Samuel Kaplan and Yvonne Bryson and Helene Cohen and Joseph Church and Arnold Platzker and Lucy Kunzman and Andrea Kovacs and Lynn Fukushima and Jenson, {Hal B.} and Yasmin Ench and Kirk Easley and Michael Kutner and Mark Schluchter and Richard Martin and Johanna Goldfarb and Douglas Moodie and Cindy Chen and Victoria Konig and Yolken, {Robert H.}",
note = "Funding Information: Received 28 November 2001; revised 25 February 2002; electronically published 31 May 2002. Financial support: National Institutes of Health (grants HR-96037, HR-96038, HR-96039, HR-96040, HR-96041, HR-96042, HR-96043, RR-00188, RR-00533, RR-00071, RR-00645, RR-00865, and RR-00043). a Study group members are listed after the text. Reprints or correspondence: Dr. Hal B. Jenson, University of Texas Health Science Center, Dept. of Pediatrics, MC 7811, 7703 Floyd Curl Dr., San Antonio, TX 78229-3900 (jenson@uthscsa.edu).",
year = "2002",
month = jun,
day = "15",
doi = "10.1086/340819",
language = "English (US)",
volume = "185",
pages = "1798--1802",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "12",
}