Evaluation of combined live, attenuated respiratory syncytial virus and parainfluenza 3 virus vaccines in infants and young children

Robert B. Belshe, Frances K. Newman, Edwin L. Anderson, Peter F. Wright, Ruth A. Karron, Sharon Tollefson, Frederick W. Henderson, H. Cody Meissner, Shabir Madhi, Don Roberton, Helen Marshall, Richard Loh, Peter Sly, Brian Murphy, Joanne M. Tatem, Valerie Randolph, Jill Hackell, William Gruber, Theodore F. Tsai

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

We evaluated a combination respiratory syncytial virus (RSV) and parainfluenza 3 virus (PIV3) live, attenuated intranasal vaccine for safety, viral replication, and immunogenicity in doubly seronegative children 6-18 months old. RSV cpts-248/404 and PIV3-cp45 vaccines were combined in a dose of 10 5 plaque-forming units of each per 0.5-mL dose and compared with monovalent vaccines or placebo. The virus shedding pattern of RSV was not different between monovalent RSV cpts-248/404 vaccine and combination vaccine. Modest reductions in the shedding of PIV3-cp45 vaccine virus were found after the administration of RSV cpts-248/404 and PIV3-cp45 vaccine, relative to monovalent PIV3 vaccine; 16 (76%) of 21 children given combination vaccine shed PIV3-cp45 versus 11 (92%) of 12 of those given monovalent PIV3 vaccine. Both vaccines were immunogenic, and antibody responses were similar between the monovalent groups and the combination group. Combined RSV/ PV3 vaccine is feasible for simultaneous administration, and further studies are warranted.

Original languageEnglish (US)
Pages (from-to)2096-2103
Number of pages8
JournalJournal of Infectious Diseases
Volume190
Issue number12
DOIs
StatePublished - Dec 15 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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