Evaluation of a Standardized Perioperative Management Protocol in the Adult Hematology Anticoagulation Management Service

Diane J. Lum, Patricia A. Ross, Martin A. Bishop, Michelle L. Caetano, Rohil Malpani, Michael B. Streiff

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: In North America, 250,000 patients on vitamin K antagonists require surgical procedures each year. Temporary interruption of oral anticoagulation and perioperative bridging therapy with unfractionated heparin or low-molecular-weight heparin are recommended by the American College of Chest Physicians 2012 for select patients. Objectives: The study objectives are to evaluate adherence and nonadherence to the Johns Hopkins clinic guidelines for perioperative management of anticoagulation and identify bleeding or thromboembolic events during perioperative management of anticoagulation. Methods: This is a retrospective study of patients who required perioperative management of anticoagulation for an invasive procedure from May 2009 to March 2014. Individualized perioperative anticoagulation management plans were prospectively developed for each patient according to the standardized Johns Hopkins perioperative bridging recommendations and documented in the medical record. Adherence to these standardized Johns Hopkins clinic guidelines, the incidence of thromboembolic events, and bleeding and adverse events during perioperative management were retrieved from the medical record. Results: In 294 perioperative management cases, there was 1 (0.3%) thromboembolism, 3 (1%) major bleeds, and 21 (7%) minor bleeds. One patient experienced facial swelling after starting enoxaparin. There was no difference in thromboembolic (0 vs 1, P = 1.00), major (1 vs 2, P = 1.00), or minor bleeding (14 vs 7, P = 1.00) events in patients managed by providers who were adherent to guidelines when compared with providers who were nonadherent. Conclusion: Our study shows that using a standardized guideline for perioperative management of anticoagulation to inform but not to dictate clinical practice leads to low rates of both thromboembolism and bleeding.

Original languageEnglish (US)
Pages (from-to)1077-1083
Number of pages7
JournalAnnals of Pharmacotherapy
Issue number12
StatePublished - Dec 1 2017


  • adherence
  • anticoagulants
  • anticoagulation
  • surgery
  • warfarin

ASJC Scopus subject areas

  • Pharmacology (medical)


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