Evaluation of a new DNA test for detection of carcinogenic human papillomavirus

Philip E. Castle; Erin C. Gutierrez; Sharon V. Leitch; Courtney E. Maus; Ray A. McMillian; William A. Nussbaumer; Laurence M. Vaughan; Cosette M. Wheeler; Patti E. Gravitt; Mark Schiffman

doi:10.1128/JCM.00422-11

Evaluation of a new DNA test for detection of carcinogenic human papillomavirus

Philip E. Castle, Erin C. Gutierrez, Sharon V. Leitch, Courtney E. Maus, Ray A. McMillian, William A. Nussbaumer, Laurence M. Vaughan, Cosette M. Wheeler, Patti E. Gravitt, Mark Schiffman

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Using archived specimens, we evaluated a new automated real-time PCR assay (BD Diagnostics) that detects all carcinogenic human papillomaviruses (HPV) and provides HPV genotyping for seven of them, including HPV16 and HPV18, the two most carcinogenic HPV genotypes. We found comparable results with Hybrid Capture 2 (HC2) for detection of carcinogenic HPV (n = 473) and with Linear Array and Line Blot Assay (n = 371) for detection of individual HPV genotypes.

Original language	English (US)
Pages (from-to)	3029-3032
Number of pages	4
Journal	Journal of clinical microbiology
Volume	49
Issue number	8
DOIs	https://doi.org/10.1128/JCM.00422-11
State	Published - Aug 2011
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)

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abstract = "Using archived specimens, we evaluated a new automated real-time PCR assay (BD Diagnostics) that detects all carcinogenic human papillomaviruses (HPV) and provides HPV genotyping for seven of them, including HPV16 and HPV18, the two most carcinogenic HPV genotypes. We found comparable results with Hybrid Capture 2 (HC2) for detection of carcinogenic HPV (n = 473) and with Linear Array and Line Blot Assay (n = 371) for detection of individual HPV genotypes.",

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AU - Gutierrez, Erin C.

AU - Leitch, Sharon V.

AU - Maus, Courtney E.

AU - McMillian, Ray A.

AU - Nussbaumer, William A.

AU - Vaughan, Laurence M.

AU - Wheeler, Cosette M.

AU - Gravitt, Patti E.

AU - Schiffman, Mark

PY - 2011/8

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AB - Using archived specimens, we evaluated a new automated real-time PCR assay (BD Diagnostics) that detects all carcinogenic human papillomaviruses (HPV) and provides HPV genotyping for seven of them, including HPV16 and HPV18, the two most carcinogenic HPV genotypes. We found comparable results with Hybrid Capture 2 (HC2) for detection of carcinogenic HPV (n = 473) and with Linear Array and Line Blot Assay (n = 371) for detection of individual HPV genotypes.

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Evaluation of a new DNA test for detection of carcinogenic human papillomavirus

Abstract

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