Evaluation of a neonatal rat model for prediction of mumps virus neurovirulence in humans

Steven A. Rubin, Mikhail Pletnikov, Rolf Taffs, Phil J. Snoy, Darwyn Kobasa, Earl G. Brown, Kathryn E. Wright, Kathryn M. Carbone

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Neurovirulence of several mumps virus strains was assessed in a prototype rat neurovirulence test and compared to results obtained in the monkey neurovirulence test. The relative human neurovirulence of these strains was proportional to the severity of hydrocephalus in rats but not to lesion scores in the monkeys.

Original languageEnglish (US)
Pages (from-to)5382-5384
Number of pages3
JournalJournal of virology
Volume74
Issue number11
DOIs
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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