Evaluation of a Live-Attenuated Human Parainfluenza Virus Type 2 Vaccine in Adults and Children

Ruth A. Karron; Kristi Herbert; Kimberli Wanionek; Alexander C. Schmidt; Anne Schaap-Nutt; Peter L. Collins; Ursula J. Buchholz

doi:10.1093/jpids/piac137

Evaluation of a Live-Attenuated Human Parainfluenza Virus Type 2 Vaccine in Adults and Children

Ruth A. Karron
, Kristi Herbert
, Kimberli Wanionek
, Alexander C. Schmidt
, Anne Schaap-Nutt
, Peter L. Collins
, Ursula J. Buchholz

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

We conducted a phase I clinical trial of the live-attenuated recombinant human parainfluenza virus type 2 (HPIV2) vaccine candidate rHPIV2-15C/948L/∆1724 sequentially in adults, HPIV2-seropositive children, and HPIV2-seronegative children, the target population for vaccination. rHPIV2-15C/948L/∆1724 was appropriately restricted in replication in adults and HPIV2-seropositive children but was overattenuated for HPIV2-seronegative children.

Original language	English (US)
Pages (from-to)	173-176
Number of pages	4
Journal	Journal of the Pediatric Infectious Diseases Society
Volume	12
Issue number	3
DOIs	https://doi.org/10.1093/jpids/piac137
State	Published - Mar 1 2023

Keywords

live-attenuated
parainfluenza
vaccine

ASJC Scopus subject areas

General Medicine

Access to Document

10.1093/jpids/piac137

Cite this

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abstract = "We conducted a phase I clinical trial of the live-attenuated recombinant human parainfluenza virus type 2 (HPIV2) vaccine candidate rHPIV2-15C/948L/∆1724 sequentially in adults, HPIV2-seropositive children, and HPIV2-seronegative children, the target population for vaccination. rHPIV2-15C/948L/∆1724 was appropriately restricted in replication in adults and HPIV2-seropositive children but was overattenuated for HPIV2-seronegative children.",

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AU - Karron, Ruth A.

AU - Herbert, Kristi

AU - Wanionek, Kimberli

AU - Schmidt, Alexander C.

AU - Schaap-Nutt, Anne

AU - Collins, Peter L.

AU - Buchholz, Ursula J.

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PY - 2023/3/1

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N2 - We conducted a phase I clinical trial of the live-attenuated recombinant human parainfluenza virus type 2 (HPIV2) vaccine candidate rHPIV2-15C/948L/∆1724 sequentially in adults, HPIV2-seropositive children, and HPIV2-seronegative children, the target population for vaccination. rHPIV2-15C/948L/∆1724 was appropriately restricted in replication in adults and HPIV2-seropositive children but was overattenuated for HPIV2-seronegative children.

AB - We conducted a phase I clinical trial of the live-attenuated recombinant human parainfluenza virus type 2 (HPIV2) vaccine candidate rHPIV2-15C/948L/∆1724 sequentially in adults, HPIV2-seropositive children, and HPIV2-seronegative children, the target population for vaccination. rHPIV2-15C/948L/∆1724 was appropriately restricted in replication in adults and HPIV2-seropositive children but was overattenuated for HPIV2-seronegative children.

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Evaluation of a Live-Attenuated Human Parainfluenza Virus Type 2 Vaccine in Adults and Children

Abstract

Keywords

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