@article{cd62e674040541dfb2f9d1fec4cc6f71,
title = "Evaluation of a Live-Attenuated Human Parainfluenza Virus Type 2 Vaccine in Adults and Children",
abstract = "We conducted a phase I clinical trial of the live-attenuated recombinant human parainfluenza virus type 2 (HPIV2) vaccine candidate rHPIV2-15C/948L/∆1724 sequentially in adults, HPIV2-seropositive children, and HPIV2-seronegative children, the target population for vaccination. rHPIV2-15C/948L/∆1724 was appropriately restricted in replication in adults and HPIV2-seropositive children but was overattenuated for HPIV2-seronegative children.",
keywords = "live-attenuated, parainfluenza, vaccine",
author = "Karron, {Ruth A.} and Kristi Herbert and Kimberli Wanionek and Schmidt, {Alexander C.} and Anne Schaap-Nutt and Collins, {Peter L.} and Buchholz, {Ursula J.}",
note = "Funding Information: RAK, KH, andKWwerefundedbyNIAIDcontractHHS272200900010C. ACS, ASN, UJB, and PLC were funded by the Intramural Program of the NIAID. The authors are grateful to Elizabeth Schappell, Karen Loehr, Suzanne Woods, Milena Gatto, and Jen Oliva for expert clinical and laboratory assistance; The Pediatric Group, Primary Pediatrics, Dundalk Pediatrics, and Johns Hopkins Community Physicians for allowing us to approach families in their practices and to the families for their participation in this study. Publisher Copyright: {\textcopyright} This work is written by (a) US Government employee(s) and is in the public domain in the US.",
year = "2023",
month = mar,
day = "1",
doi = "10.1093/jpids/piac137",
language = "English (US)",
volume = "12",
pages = "173--176",
journal = "Journal of the Pediatric Infectious Diseases Society",
issn = "2048-7193",
publisher = "Oxford University Press",
number = "3",
}